American Journal of Otolaryngology - Head and Neck Medicine and Surgery
Volume 24, Issue 1 , Pages 14-18 , January 2003

Mastoid obliteration by BMP-2/collagen composites: An experimental study using tissue engineering

  • Image Result

    One week after implantation. Heterogenic bone formation is seen. Implanted collagen (IC), woven bone (WB), and chondrocytes (arrows) are shown.

    One week after implantation. Heterogenic bone formation is seen. Implanted collagen (IC), woven bone (WB), and chondrocytes (arrows) are shown.

  • Image Result

    Two weeks after implantation. Woven bone (WB) is maturing and many vessels (arrows) are forming by angiogenesis.

    Two weeks after implantation. Woven bone (WB) is maturing and many vessels (arrows) are forming by angiogenesis.

  • Image Result

    Four weeks after implantation. Bone marrow separated by bone trabeculae (T) is formed. Adipose tissue (A) and hematopoietic tissue (H) are shown.

    Four weeks after implantation. Bone marrow separated by bone trabeculae (T) is formed. Adipose tissue (A) and hematopoietic tissue (H) are shown.

  • Image Result

    Eight weeks after implantation. The place where newly formed bone (B) is adhesive to the osseous labyrinth (O) is shown.

    Eight weeks after implantation. The place where newly formed bone (B) is adhesive to the osseous labyrinth (O) is shown.

  • Image Result

    Twenty-four weeks after implantation. A row of osteoclasts (arrows) in the bone marrow is still surrounding the newly formed bone. Osteocytes (arrowheads) are shown.

    Twenty-four weeks after implantation. A row of osteoclasts (arrows) in the bone marrow is still surrounding the newly formed bone. Osteocytes (arrowheads) are shown.

 Address correspondence to: Kazunori Nishizaki, MD, Department of Otolaryngology–Head and Neck Surgery, Okayama University Graduate School, 700-8558 Japan. E-mail: nishizak@cc.okayama-u.ac.jp.

PII: S0196-0709(02)32415-3

doi: 10.1053/ajot.2003.13

American Journal of Otolaryngology - Head and Neck Medicine and Surgery
Volume 24, Issue 1 , Pages 14-18 , January 2003