American Journal of Otolaryngology - Head and Neck Medicine and Surgery
Volume 27, Issue 2 , Pages 81-85 , March 2006

Cyclooxygenase 2 expression in otitis media with effusion

  • Masashi Kakiuchi, MD

      Affiliations

    • Department of Otolaryngology–Head and Neck Surgery, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
  • ,
  • Hidetsugu Tsujigiwa, PhD

      Affiliations

    • Department of Oral Pathology and Medicine, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
  • ,
  • Yorihisa Orita, MD

      Affiliations

    • Department of Otolaryngology–Head and Neck Surgery, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    • Corresponding Author InformationCorresponding author. Department of Otolaryngology–Head and Neck Surgery, Okayama School of Medicine and Dentistry, 2-5-1 Shikata-Cho, Okayama-Shi, Okayama 700-8558, Japan. Tel.: +81 86 235 6652; fax: +81 86 235 6654.
  • ,
  • Hitoshi Nagatsuka, DDS

      Affiliations

    • Department of Oral Pathology and Medicine, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
  • ,
  • Junko Yoshinobu, BS

      Affiliations

    • Department of Otolaryngology–Head and Neck Surgery, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
  • ,
  • Shin Kariya, MD

      Affiliations

    • Department of Otolaryngology–Head and Neck Surgery, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
  • ,
  • Shin-Ichi Haginomori, MD

      Affiliations

    • Department of Otolaryngology–Head and Neck Surgery, Osaka Medical College, Osaka, Japan
  • ,
  • Saeko Orita, MD

      Affiliations

    • Department of Otolaryngology–Head and Neck Surgery, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
  • ,
  • Kunihiro Fukushima, MD

      Affiliations

    • Department of Otolaryngology–Head and Neck Surgery, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
  • ,
  • Mitsuhiro Okano, MD

      Affiliations

    • Department of Otolaryngology–Head and Neck Surgery, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
  • ,
  • Noriyuki Nagai, DDS

      Affiliations

    • Department of Oral Pathology and Medicine, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
  • ,
  • Kazunori Nishizaki, MD

      Affiliations

    • Department of Otolaryngology–Head and Neck Surgery, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan

Received 8 April 2005

References 

  1. Crofford LJ. COX-1 and COX-2 tissue expression: implications and predictions. J Rheumatol. 1997;(24 Suppl 49):15–19
  2. Vane JR, Bakhle YS, Botting RM. Cyclooxygenases 1 and 2. Annu Rev Pharmacol Toxicol. 1998;38:97–120
  3. Song AM, Bhagat L, Singh VP, et al. Inhibition of cyclooxygenase-2 ameliorates the severity of pancreatitis and associated lung injury. Am J Physiol Gastrointest Liver Physiol. 2002;283:G1166–G1174
  4. McGeer PL, McGeer EG, Yasojima K. Expression of COX-1 and COX-2 mRNAs in atherosclerotic plaques. Exp Gerontol. 2002;37:925–929
  5. Cornetta AJ, Russell JP, Cunnane M. Cyclooxygenase-2 expression in human thyroid carcinoma and Hashimoto's thyroiditis. Laryngoscope. 2002;112:238–242
  6. Hirsch BE. Otitis media, myringotomy, and tympanostomy tubes. In:  Myers EN editors. 1st ed.. Operative otolaryngology head and neck surgery. vol. 2:Philadelphia: WB Saunders; 1997;p. 1236–1245
  7. Hochberg MC. Treatment of rheumatoid arthritis and osteoarthritis with COX-2–selective inhibitors: a managed care perspective. Am J Manag Care. 2002;8(17 Suppl):S502–S517
  8. Krekorian TD, Keithley EM, Takahashi M. Endotoxin-induced otitis media with effusion in the mouse. Acta Otolaryngol (Stockh). 1990;109:288–299
  9. Flesher AR, Insel RA. Characterization of lipopolysaccharide of Haemophilus influenzae. J Infect Dis. 1978;138:719–730
  10. Park CW, Han JH, Jeong JH, et al. Detection rates of bacteria in chronic otitis media with effusion in children. J Korean Med Sci. 2004;19:735–738
  11. Sando I, Takahashi H. Otitis media associated with various congenital disease. Preliminary study. Ann Otol Rhinol Laryngol Suppl. 1990;148:13–16
  12. Hla T, Neilson K. Human cyclooygenase-2 cDNA. Proc Natl Acad Sci U S A. 1992;89:7384–7388
  13. Goldie P, Jung TK, Helstrom SH. Arachidonic acid metabolites in experimental otitis media and effects of anti-inflammatory drugs. Ann Otol Rhinol Laryngol. 1993;102:954–959
  14. Nakata J, Suzuki M, Kawauchi H, et al. Experimental otitis media with effusion induced by middle ear effusion. Laryngoscope. 1992;102:1037–1042
  15. Herman P, Yen PT, Tu TY, et al. Pathophysiology of middle ear epithelium: a new role for prostaglandin E2. Am J Otolaryngol. 1994;15:258–266
  16. Forseni M, Melhus A, Ryan AF, et al. Detection and localization of interleukin-6 in the rat middle ear during experimental acute otitis media, using mRNA in situ hybridization and immunohistochemistry. Int J Pediatr Otorhinolaryngol. 2001;57:115–121
  17. Tong HH, Chen Y, James M, et al. Expression of cytokine and chemokine genes by human middle ear epithelial cells induced by formalin-killed Haemophilus influenzae or its lipooligosaccharide htrD and rfaD mutants. Infect Immun. 2001;69:3678–3684
  18. Diven WF, Evans RW, Alper C, et al. Treatment of experimental acute otitis media with ibuprofen and ampicillin. Int J Pediatr Otorhinolaryngol. 1995;33:127–139
  19. Weckx LL, Ruiz JE, Duperly J, et al. Efficacy of celecoxib in treating symptoms of viral pharyngitis: a double-blind, randomized study of celecoxib versus diclofenac. J Int Med Res. 2002;30:185–194
  20. Narayanan BA, Narayanan NK, Pittman B, et al. Regression of mouse prostatic intraepithelial neoplasia by nonsteroidal anti-inflammatory drugs in the transgenic adenocarcinoma mouse prostate model. Clin Cancer Res. 2004;10:7727–7737
  21. Farkouh ME, Kirshner H, Harrington RA, et al. Comparison of lumiracoxib with naproxen and ibuprofen in the Therapeutic Arthritis Research and Gastrointestinal Event Trial (TARGET), cardiovascular outcomes: randomized trial. Lancet. 2004;364:639–640
  22. Claria J, Kent JD, Lopez-Parra M, et al. Effects of celecoxib and naproxen on renal function in nonazotemic patients with cirrhosis and ascites. Hepatology. 2005;41:579–587
  23. Hampton T. Experts point to lessons learned from controversy over rofecoxib safety. JAMA. 2005;293:413–414
  24. Silverstein FE, Faich G, Goldstein JL, et al. Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis: the CLASS study: a randomized controlled trial. Celecoxib Long-term Arthritis Safety Study. JAMA. 2000;284:1247–1255
  25. Lin DT, Subbaramaiah K, Shah JP, et al. Cyclooxygenase-2: a novel molecular target of head and neck cancer. Head Neck. 2002;24:792–799
  26. Jin YT, Tsai ST, Li C, et al. Prevalence of human papillomavirus in middle ear carcinoma associated with chronic otitis media. Am J Pathol. 1997;150:1327–1333
  27. Jung TTK, Berlinger NT, Juhn SK. Prostaglandins in squamous cell carcinoma of the head and neck: a preliminary study. Laryngoscope. 1985;95:307–312

PII: S0196-0709(05)00138-9

doi: 10.1016/j.amjoto.2005.07.009

American Journal of Otolaryngology - Head and Neck Medicine and Surgery
Volume 27, Issue 2 , Pages 81-85 , March 2006