American Journal of Otolaryngology - Head and Neck Medicine and Surgery
Volume 27, Issue 2 , Pages 119-128, March 2006

Gastroesophageal reflux and laryngeal cancer: causation or association? A critical review

  • Mohammed A. Qadeer, MD

      Affiliations

    • Department of Gastroenterology and Hepatology, Cleveland Clinic Foundation, Cleveland, OH, USA
    • ,
  • Natalie Colabianchi, PhD

      Affiliations

    • Department of Epidemiology, Case Western Reserve University, Cleveland, OH, USA
    • ,
  • Marshall Strome, MD

      Affiliations

    • Department of Otolaryngology, Cleveland Clinic Foundation, Cleveland, OH, USA
    • ,
  • Michael F. Vaezi, MD, PhD, MSepi

      Affiliations

    • Department of Gastroenterology and Hepatology, Cleveland Clinic Foundation, Cleveland, OH, USA
    • Corresponding Author InformationCorresponding author. 1501 TVC, 1301 22nd Avenue South, Nashville, TN 37232-5280, USA. Tel.: +1 615 322 0128; fax: +1 615 343 8174.

Received 19 November 2004

Abstract 

Gastroesophageal reflux disease has been implicated as a causative factor in several laryngeal disorders. Its involvement in laryngeal cancer is of interest not only from a clinicopathologic aspect, but also from a public health perspective. However, despite a number of studies, a causal relationship with laryngeal cancer is uncertain. In this article, we address the current literature in a critical manner to facilitate the understanding of this subject and evaluate the relationship between gastroesophageal reflux disease and laryngeal carcinoma.

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PII: S0196-0709(05)00139-0

doi:10.1016/j.amjoto.2005.07.010

American Journal of Otolaryngology - Head and Neck Medicine and Surgery
Volume 27, Issue 2 , Pages 119-128, March 2006

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