American Journal of Otolaryngology - Head and Neck Medicine and Surgery
Volume 27, Issue 2 , Pages 101-105 , March 2006

Correlation between proliferating cell nuclear antigen and p53 protein expression and 5-year survival rate in nasopharyngeal carcinoma

This manuscript has been presented at the 77th Conference of Taiwan Otolaryngological Society; November 13-14, 2004; Taipei, Taiwan.

  • Ling-Feng Wang, MD

      Affiliations

    • Department of Otolaryngology-Head and Neck Surgery, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC
  • ,
  • Chee-Yin Chai, MD, PhD

      Affiliations

    • Department of Pathology, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC
    • Department of Pathology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC
  • ,
  • Wen-Rei Kuo, MD

      Affiliations

    • Department of Otolaryngology-Head and Neck Surgery, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC
    • Department of Otolaryngology-Head and Neck Surgery, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC
  • ,
  • Chih-Feng Tai, MD

      Affiliations

    • Department of Otolaryngology-Head and Neck Surgery, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC
    • Department of Otolaryngology-Head and Neck Surgery, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC
  • ,
  • Ka-Wo Lee, MD

      Affiliations

    • Department of Otolaryngology-Head and Neck Surgery, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC
    • Department of Otolaryngology-Head and Neck Surgery, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC
  • ,
  • Kuen-Yao Ho, MD

      Affiliations

    • Department of Otolaryngology-Head and Neck Surgery, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC
    • Department of Otolaryngology-Head and Neck Surgery, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC
    • Corresponding Author InformationCorresponding author. Department of Otolaryngology, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan, ROC. Tel.: +886 7 3208264.

References 

  1. Al-Sarraf M, LeBlanc M, Giri PG, et al. Chemoradiotherapy versus radiotherapy in patients with advanced nasopharyngeal cancer: phase III randomized Intergroup study 0099. J Clin Oncol. 1998;16(4):1310–1317
  2. Lin JC, Jan JS, Hsu CY, et al. Outpatient weekly neoadjuvant chemotherapy followed by radiotherapy for advanced nasopharyngeal carcinoma: high complete response and low toxicity rates. Br J Cancer. 2003;88(2):187–194
  3. Lin JC, Jan JS, Hsu CY, et al. Phase III study of concurrent chemoradiotherapy versus radiotherapy alone for advanced nasopharyngeal carcinoma: positive effect on overall and progression-free survival. J Clin Oncol. 2003;21(4):631–637
  4. Marks JE, Phillips JL, Menck HR. The National Cancer Data Base report on the relationship of race and national origin to the histology of nasopharyngeal carcinoma. Cancer. 1998;83(3):582–588
  5. Mayer A, Takimoto M, Fritz E, et al. The prognostic significance of proliferating cell nuclear antigen, epidermal growth factor receptor, and mdr gene expression in colorectal cancer. Cancer. 1993;71(8):2454–2460
  6. Thomas H, Nasim MM, Sarraf CE, et al. Proliferating cell nuclear antigen (PCNA) immunostaining—a prognostic factor in ovarian cancer?. Br J Cancer. 1995;71(2):357–362
  7. Jain S, Filipe MI, Hall PA, et al. Prognostic value of proliferating cell nuclear antigen in gastric carcinoma. J Clin Pathol. 1991;44(8):655–659
  8. Lipponen PK, Eskelinen MJ. Cell proliferation of transitional cell bladder tumours determined by PCNA/cyclin immunostaining and its prognostic value. Br J Cancer. 1992;66(1):171–176
  9. Oka K, Hoshi T, Arai T. Prognostic significance of the PC10 index as a prospective assay for cervical cancer treated with radiation therapy alone. Cancer. 1992;70(6):1545–1550
  10. Heegaard S, Sommer HM, Broholm H, et al. Proliferating cell nuclear antigen and Ki-67 immunohistochemistry of oligodendrogliomas with special reference to prognosis. Cancer. 1995;76(10):1809–1813
  11. Chan AT, Ho S, Teo PM, et al. Assessment of proliferating cell nuclear antigen in nasopharyngeal carcinoma tissue and its relation to clinical findings. Oral Oncol. 1997;3(1):13–18
  12. Genç E, Hosal AS, Gedikoglu G, et al. Prognostic value of p53, proliferating cell nuclear antigen, and Ki-67 expression in undifferentiated nasopharyngeal carcinomas. Otolaryngol Head Neck Surg. 2000;122(6):868–873
  13. Tsai ST, Jin YT, Leung HW, et al. Bcl-2 and proliferating cell nuclear antigen (PCNA) expression correlates with subsequent local recurrence in nasopharyngeal carcinomas. Anticancer Res. 1998;18(4B):2849–2854
  14. Lowe SW, Ruley HE, Jacks T, et al. p53-Dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell. 1993;74(6):957–967
  15. Caffo O, Doglioni C, Veronese S, et al. Prognostic value of p21(WAF1) and p53 expression in breast carcinoma: an immunohistochemical study in 261 patients with long-term follow-up. Clin Cancer Res. 1996;2(9):1591–1599
  16. Kawasaki M, Nakanishi Y, Kuwano K, et al. The utility of p53 immunostaining of transbronchial biopsy specimens of lung cancer: p53 overexpression predicts poor prognosis and chemoresistance in advanced non–small cell lung cancer. Clin Cancer Res. 1997;3(7):1195–1200
  17. Quon H, Liu FF, Cummings BJ. Potential molecular prognostic markers in head and neck squamous cell carcinomas. Head Neck. 2001;23(2):147–159
  18. Shin DM, Voravud N, Ro JY, et al. Sequential increases in proliferating cell nuclear antigen expression in head and neck tumorigenesis: a potential biomarker. J Natl Cancer Inst. 1993;85(12):971–978
  19. Kouvidou C, Stefanaki K, Dai Y, et al. p21/WAF 1 protein expression in nasopharyngeal carcinoma. Comparative study with PCNA, p53 and MDM-2 protein expression. Anticancer Res. 1997;17(4A):2615–2619
  20. Niemhom S, Kitazawa S, Murao S, et al. Co-expression of p53 and bcl-2 may correlate to the presence of Epstein-Barr virus genome and the expression of proliferating cell nuclear antigen in nasopharyngeal carcinoma. Cancer Lett. 2000;160(2):199–208
  21. Hall PA, Coates PJ, Goodlad RA, et al. Proliferating cell nuclear antigen expression in non-cycling cells may be induced by growth factors in vivo. Br J Cancer. 1994;70(2):244–247
  22. Kastan MB, Onyekwere O, Sidransky D, et al. Participation of p53 protein in the cellular response to DNA damage. Cancer Res. 1991;51(23 Pt. 1):6304–6311
  23. Lee JM, Bernstein A. p53 Mutations increase resistance to ionizing radiation. Proc Natl Acad Sci U S A. 1993;90(12):5742–5746
  24. Faccioli S, Cavicchi O, Caliceti U, et al. Cell proliferation as an independent predictor of survival for patients with advanced nasopharyngeal carcinoma. Mod Pathol. 1997;10(9):884–894
  25. Shi W, Pataki I, MacMillan C, et al. Molecular pathology parameters in human nasopharyngeal carcinoma. Cancer. 2002;94(7):1997–2006
  26. Ma BB, Poon TC, To KF, et al. Prognostic significance of tumor angiogenesis, Ki-67, p53 oncoprotein, epidermal growth factor receptor and HER2 receptor protein expression in undifferentiated nasopharyngeal carcinoma—a prospective study. Head Neck. 2003;25(10):864–872
  27. Masuda M, Shinokuma A, Hirakawa N, et al. Expression of bcl-2-, p53, and Ki-67 and outcome of patients with primary nasopharyngeal carcinomas following DNA-damaging treatment. Head Neck. 1998;20(7):640–644
  28. Sheu LF, Chen A, Tseng HH, et al. Assessment of p53 expression in nasopharyngeal carcinoma. Hum Pathol. 1995;26(4):380–386

 This study was supported by a grant from the Research Department of Kaohsiung Medical University, Kaohsiung, Taiwan (M930026).

PII: S0196-0709(05)00147-X

doi: 10.1016/j.amjoto.2005.07.018

American Journal of Otolaryngology - Head and Neck Medicine and Surgery
Volume 27, Issue 2 , Pages 101-105 , March 2006