American Journal of Otolaryngology - Head and Neck Medicine and Surgery
Volume 27, Issue 4 , Pages 229-232 , July 2006

Recurrent aphthous stomatitis: investigation of possible etiologic factors

  • Serap Koybasi, MD

      Affiliations

    • Department of Otolaryngology, Abant Izzet Baysal University, Izzet Baysal Faculty of Medicine, Bolu, Turkey
    • Corresponding Author InformationCorresponding author. Department of Otolaryngology, Abant Izzet Baysal University, Izzet Baysal Faculty of Medicine, Bolu 14280, Turkey. Tel.: +90 374 253 4656; fax: +90 374 253 4615.
    • ,
  • Ali Haydar Parlak, MD

      Affiliations

    • Department of Dermatology, Abant Izzet Baysal University, Izzet Baysal Faculty of Medicine, Bolu, Turkey
    • ,
  • Erdinc Serin, MD

      Affiliations

    • Department of Biochemistry, Abant Izzet Baysal University, Izzet Baysal Faculty of Medicine, Bolu, Turkey
    • ,
  • Fahrettin Yilmaz, MD

      Affiliations

    • Department of Otolaryngology, Abant Izzet Baysal University, Izzet Baysal Faculty of Medicine, Bolu, Turkey
    • ,
  • Didem Serin, MD

      Affiliations

    • Department of Ophthalmology, Abant Izzet Baysal University, Izzet Baysal Faculty of Medicine, Bolu, Turkey

Received 17 August 2005

References 

  1. Axell T, Henricson V. The occurrence of recurrent aphthous stomatitis in adult Swedish population. Acta Odontol Scand. 1985;43:121–125
  2. Ship II. Epidemiological aspects of recurrent aphthous ulcerations. Oral Surg. 1972;33:400–406
  3. Ship JA. Recurrent aphthous stomatitis. An update. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1996;81:141–147
  4. Ogura M, Yamamoto T, Morita M, et al. A case control study on food intake of patients with recurrent aphthous stomatitis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001;91:45–49
  5. Nolan A, Lamey P-J, Milligan KA, et al. Recurrent aphthous stomatitis and food sensitivity. J Oral Pathol Med. 1991;20:473–475
  6. Piskin S, Syan C, Durukan N, et al. Serum iron, ferritin, folic acid and vitamin B12 levels in recurrent aphthous stomatitis. J Eur Acad Dermatol Venereol. 2002;16:66–67
  7. Scully C, Gorsky M, Lozada-Nur F. Aphthous ulcerations. Dermatol Ther. 2002;15:185–205
  8. Miller MF, Garfunkel AA, Ram C, et al. Inheritance patterns in recurrent aphthous ulcers: twin and pedigree data. Oral Surg Oral Med Oral Pathol. 1977;43:886–891
  9. Miller MF, Garfunkel AA, Ram CA, et al. The inheritance of recurrent aphthous stomatitis. Observations on susceptibility. Oral Surg. 1980;94:18–23
  10. Shohat-Zabarski R, Kalderon S, Klein T, et al. Close association of HLA-B51 in persons with recurrent aphthous stomatitis. Oral Surg Oral Med Oral Pathol. 1992;74:463–465
  11. Weusten BLAM, Wiel AV. Aphthous ulcers and vit B12 deficiency. Neth J Med. 1998;53:172–175
  12. Palopoli J, Waxman J. Recurrent aphthous stomatitis and vitamin B12 deficiency. South Med J. 1990;83:475–477
  13. Wray D, Ferguson MM, Hutcheon AW, et al. Nutritional deficiencies in recurrent aphthae. J Oral Pathol. 1978;7:418–423
  14. Nolan A, McIntosh WB, Allam BF, et al. Recurrent aphthous ulceration: vitamin B1, B2 and B6 status and response to replacement therapy. J Oral Pathol Med. 1991;20:389–391
  15. Wray D, Ferguson MM, Mason DK, et al. Recurrent aphthae: treatment with vitamin B12, folic acid, and iron. Br Med J. 1975;2:490–493
  16. Shapiro S, Olson DL, Chellimi SJ. The association between smoking and aphthous ulcers. Oral Surg Oral Med Oral Pathol. 1970;30:624–630
  17. Bittoun R. Recurrent aphthous ulcers and nicotine. Med J Aust. 1991;154:471–472
  18. Tuzun B, Wolf R, Tuzun Y, et al. Recurrent aphthous stomatitis and smoking. Int J Dermatol. 2000;39:358–360
  19. Porter SR, Scully C, Flint S. Hematologic status in recurrent aphthous stomatitis compared with other oral diseases. Oral Surg Oral Med Oral Pathol. 1988;66:41–44
  20. Olson JA, Feinberg I, Silverman S, et al. Serum vitamin B12 folate and iron levels in recurrent aphthous ulceration. Oral Surg. 1982;54:517–520

PII: S0196-0709(05)00190-0

doi: 10.1016/j.amjoto.2005.09.022

American Journal of Otolaryngology - Head and Neck Medicine and Surgery
Volume 27, Issue 4 , Pages 229-232 , July 2006

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