Otosclerosis: etiopathogenesis and histopathology

Cureoglu, Sebahattin; Schachern, Patricia A.; Ferlito, Alfio; Rinaldo, Alessandra; Tsuprun, Vladimir; Paparella, Michael M.

doi:10.1016/j.amjoto.2005.11.001

« Previous Next »American Journal of Otolaryngology - Head and Neck Medicine and Surgery
Volume 27, Issue 5 , Pages 334-340, September 2006

Otosclerosis: etiopathogenesis and histopathology☆

Sebahattin Cureoglu, MD
- Department of Otolaryngology, University of Minnesota, Minneapolis, MN, USA
Patricia A. Schachern, BS
- Department of Surgical Sciences, ENT Clinic, University of Udine, Udine, Italy
Alfio Ferlito, MD, DLO, DPath, FRSM, FRCSEd, FRCS, FASCP, FRCSGlasg, FRCSI, MCAP, FACS, FRCPath, FHKCORL, FDSRCS
- Department of Surgical Sciences, ENT Clinic, University of Udine, Udine, Italy
- Corresponding reviewer. Department of Surgical Sciences, ENT Clinic, University of Udine, Policlinico Universitario, Piazzale S. Maria della Misericordia, I-33100 Udine, Italy. Tel.: +39 0432 559302; fax: +39 0432 559339.
Alessandra Rinaldo, MD
- Department of Surgical Sciences, ENT Clinic, University of Udine, Udine, Italy
Vladimir Tsuprun, MD
- Department of Otolaryngology, University of Minnesota, Minneapolis, MN, USA
Michael M. Paparella, MD
- Department of Otolaryngology, University of Minnesota, Minneapolis, MN, USA

Abstract

Otosclerosis is a disease of the bony labyrinth manifesting clinically as a progressive conductive hearing loss, a mixed-type hearing loss, or a sensorineural hearing loss. The age of onset of the hearing loss caused by otosclerosis is principally between 15 and 40 years. Although histopathological inner ear changes due to otosclerosis have been very well documented, the true etiopathogenesis of the disease has yet to be described despite intensive research. Both genetic and environmental factors have been implicated, however.