American Journal of Otolaryngology - Head and Neck Medicine and Surgery
Volume 27, Issue 4 , Pages 248-254 , July 2006

Efficacy/safety of amoxicillin/clavulanate in adults with bacterial rhinosinusitis

  • Jack B. Anon, MD

      Affiliations

    • Department of Otolaryngology, University of Pittsburgh College of Medicine, Erie, PA, USA
    • Corresponding Author InformationCorresponding author. Department of Otolaryngology, University of Pittsburgh College of Medicine, Erie, PA 16508, USA. Tel.: +1 412 647 2100.
    • ,
  • Elchonon Berkowitz, PhD

      Affiliations

    • GlaxoSmithKline, Collegeville, PA, USA
    • ,
  • John Breton, MCM

      Affiliations

    • GlaxoSmithKline, Collegeville, PA, USA
    • ,
  • Monique Twynholm, MSc

      Affiliations

    • GlaxoSmithKline, Greenford, UK

References 

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  19. Camacho AE, Cobo R, Otte J, et al. Clinical comparison of cefuroxime axetil and amoxicillin/clavulanate in the treatment of patients with acute bacterial maxillary sinusitis. Am J Med. 2002;93:271–276
  20. Petitpretz P, Chidiac C, Soriano F, et al. The efficacy and safety of oral pharmacokinetically enhanced amoxycillin-clavulanate 2000/125 mg, twice daily, versus oral amoxycillin-clavulanate 1000/125 mg, three times daily, for the treatment of bacterial community-acquired pneumonia in adults. Int J Antimicrob Agents. 2002;20:119–129
  21. Garau J, Twynholm M, Garcia-Mendez E, et al. Oral pharmacokinetically enhanced co-amoxiclav 2000/125 mg, twice daily, compared with co-amoxiclav 875/125 mg, three times daily, in the treatment of community-acquired pneumonia in European adults. J Antimicrob Chemother. 2003;52:826–836
  22. File TMJ, Lode H, Kurz H, et al. Double-blind, randomized study of the efficacy and safety of oral pharmacokinetically enhanced amoxicillin-clavulanate (2000/125 milligrams) versus those of amoxicillin-clavulanate (875/125 milligrams), both given twice daily for 7 days, in treatment of bacterial community-acquired pneumonia in adults. Antimicrob Agents Chemother. 2004;48:3323–3331
  23. Nagai K, Appelbaum PC, Davies TA, et al. Susceptibilities to telithromycin and six other agents and prevalence of macrolide resistance due to L4 ribosomal protein mutation among 992 pneumococci from 10 central and eastern European countries. Antimicrob Agents Chemother. 2002;46:371–377
  24. Pfaller MA, Ehrhardt AF, Jones RN. Frequency of pathogen occurrence and antimicrobial susceptibility among community-acquired respiratory tract infections in the respiratory surveillance program study: microbiology from the medical office practice environment. Am J Med. 2001;111(Suppl 9A):4S–12S
  25. Poole MD, Ferguson BJ, J.-M. Klossek, et al. Pharmacokinetically enhanced amoxicillin/clavulanate, 2000/125 mg, twice daily for 10 days, in the treatment of acute bacterial rhinosinusitis. Ear Nose Throat J [in press].

☆ This study was funded by GlaxoSmithKline.

PII: S0196-0709(05)00228-0

doi: 10.1016/j.amjoto.2005.11.015

American Journal of Otolaryngology - Head and Neck Medicine and Surgery
Volume 27, Issue 4 , Pages 248-254 , July 2006

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