American Journal of Otolaryngology - Head and Neck Medicine and Surgery
Volume 28, Issue 1 , Pages 31-36 , January 2007

Expression of Bax, p53, and p27/kip in patients with papillary thyroid carcinoma with or without cervical nodal metastasis

  • Turgut Karlidag, MD

      Affiliations

    • Department of Otorhinolaryngology, Medical Faculty, Firat University, Elazig, Turkey
    • Corresponding Author InformationCorresponding author. Department of Otorhinolaryngology, Medical Faculty, Firat University, Elazig, Turkey. Tel.: +90 424 233 35 55; fax : +90 424 238 76 88.
    • ,
  • Bengu Cobanoglu, MD

      Affiliations

    • Department of Pathology, Medical Faculty, Firat University, Elazig, Turkey
    • ,
  • Erol Keles, MD

      Affiliations

    • Department of Otorhinolaryngology, Medical Faculty, Firat University, Elazig, Turkey
    • ,
  • Hayrettin Cengiz Alpay, MD

      Affiliations

    • Department of Otorhinolaryngology, Medical Faculty, Firat University, Elazig, Turkey
    • ,
  • Ibrahim Ozercan, MD

      Affiliations

    • Department of Pathology, Medical Faculty, Firat University, Elazig, Turkey
    • ,
  • Irfan Kaygusuz, MD

      Affiliations

    • Department of Otorhinolaryngology, Medical Faculty, Firat University, Elazig, Turkey
    • ,
  • Sinasi Yalcin, MD

      Affiliations

    • Department of Otorhinolaryngology, Medical Faculty, Firat University, Elazig, Turkey
    • ,
  • Oner Sakallioglu, MD

      Affiliations

    • Department of Otorhinolaryngology, Medical Faculty, Firat University, Elazig, Turkey

Received 15 May 2006

References 

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  3. Hay ID, Bergstralh EJ, Goellner JR, et al. Predicting outcome in papillary thyroid carcinoma: development of a reliable prognostic scoring system in a cohort of 1779 patients surgically treated at an institution during 1940 through 1989. Surgery. 1993;114:1050–1058
  4. Shaha AR. Management of the neck in thyroid cancer. Otolaryngol Clin North Am. 1998;31:823–831
  5. Grebe SK, Hay ID. Thyroid cancer nodal metastases: biologic significance and therapeutic considerations. Surg Oncol Clin N Am. 1996;5:43–63
  6. Khoo MLC, Freeman JL, Witterick IJ, et al. Underexpression of p27/Kip in Thyroid papillary microcarcinomas with gross metastatic disease. Arch Otolaryngol Head Neck Surg. 2002;128:253–257
  7. Resnick MB, Schacter P, Finkelstein Y, et al. Immunohistochemical analysis of p27/kip1 expression in thyroid carcinoma. Mod Pathol. 1998;11:735–739
  8. Lloyd RV, Jin L, Qian X, et al. Aberrant p27/kip1 expression in endocrine and other tumors. Am J Pathol. 1997;150:401–407
  9. Florenes VA, Maelandsmo GM, Kerbel R, et al. Protein expression of the cell-cycle inhibitor p27/Kip1 in malignant melanoma. Am J Pathol. 1998;153:305–312
  10. Steeg PS, Abrams JS. Cancer prognostics: past, present and p27/Kip1. Nat Med. 1997;3:152–154
  11. Donghi R, Longoni A, Pilotti S, et al. Gene p53 mutations are restricted to poorly differentiated and undifferentiated carcinomas of the thyroid gland. J Clin Invest. 1993;91:1753–1760
  12. Manetto V, Lorenzini R, Cordon-Cardo C, et al. Bcl-2 and Bax expression in thyroid tumours. An immunohistochemical and western blot analysis. Virchows Arch. 1997;430:125–130
  13. Hermann S, Sturm I, Mrozek A, et al. Bax expression in benign and malignant thyroid tumours: dysregulation of wild-type P53 is associated with a high Bax and P21 expression in thyroid carcinoma. Int J Cancer. 2001;92:805–811
  14. Bhattacharyya N. A population-based analysis of survival factors in differentiated and medullary thyroid carcinoma. Otolaryngol Head Neck Surg. 2003;128:115–123
  15. Hughes CJ, Shaha AR, Shah JP, et al. Impact of lymph node metastasis in differentiated carcinoma of the thyroid: a matched-pair analysis. Head Neck. 1996;18:127–132
  16. Beasley NJP, Lee J, Eski S, et al. Impact of nodal metastases on prognosis in patients with well differentiated thyroid cancer. Arch Otolaryngol Head Neck Surg. 2002;128:825–828
  17. Wang TS, Dubner S, Sznyter LA, et al. Incidence of metastatic well-differentiated thyroid cancer in cervical lymph nodes. Arch Otolaryngol Head Neck Surg. 2004;130:110–113
  18. Mazzaferri EL, Jhiang SM. Long-term impact of initial surgical and medical therapy on papillary and follicular thyroid cancer. Am J Med. 1994;97:418–428
  19. Farid P, Gomb SZ, Peter I, et al. Bcl2, p53 and bax in thyroid tumors and their relation to apoptosis. Neoplasma. 2001;48:299–301
  20. Hosal SA, Apel RL, Freeman JL, et al. Immunohistochemical localization of p53 in human thyroid neoplasms—correlation with biological behavior. Endocr Pathol. 1997;8:21–28
  21. Godballe C, Asschenfeldt P, Jorgensen KE, et al. Prognostic factors in papillary and follicular thyroid carcinomas: p53 expression is a significant indicator of prognosis. Laryngoscope. 1998;108:243–249
  22. Dobashi Y, Sakamoto A, Sugiyama H, et al. Overexpression of p53 as a possible prognostic factor in human thyroid carcinoma. Am J Surg Path. 1993;17:375–381
  23. Erickson LA, Yousef OM, Jin L, et al. p27kip1 expression distinguishes papillary hyperplasia in Graves' disease from papillary thyroid carcinoma. Mod Pathol. 2000;13:1014–1019
  24. Tallini G, Garcia-Rostan G, Herrero A, et al. Downregulation of p27KIP1 and KI67/MIB-1 labeling index support the classification of thyroid carcinoma into prognostically relevant categories. Am J Surg Pathol. 1999;23:678–685
  25. Gross ND, Weissman JL, Talbot JM, et al. MRI detection of cervical metastasis from differentiated thyroid carcinoma. Laryngoscope. 2001;111:1905–1909

PII: S0196-0709(06)00116-5

doi: 10.1016/j.amjoto.2006.06.008

American Journal of Otolaryngology - Head and Neck Medicine and Surgery
Volume 28, Issue 1 , Pages 31-36 , January 2007

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