American Journal of Otolaryngology - Head and Neck Medicine and Surgery
Volume 28, Issue 1 , Pages 46-49 , January 2007

Hypothyroidism after radiotherapy for patients with head and neck cancer

  • Hiroyuki Ozawa, MD

      Affiliations

    • Department of Otolaryngology, Keio University School of Medicine, Tokyo, Japan
    • Department of Otolaryngology, Saiseikai Utsunomiya Hospital, Tochigi, Japan
    • Corresponding Author InformationCorresponding author. Department of Otolaryngology, Keio University School of Medicine, 35, Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan. Tel.: +81 3 3353 1211; fax: +81 3 3353 1261.
    • ,
  • Hideyuki Saitou

      Affiliations

    • Department of Otolaryngology, Keio University School of Medicine, Tokyo, Japan
    • Department of Otolaryngology, Saiseikai Utsunomiya Hospital, Tochigi, Japan
    • ,
  • Kunio Mizutari

      Affiliations

    • Department of Otolaryngology, Saiseikai Utsunomiya Hospital, Tochigi, Japan
    • Department of Otolaryngology, National Tokyo Medical Center, Tokyo, Japan
    • ,
  • Yasunori Takata

      Affiliations

    • Department of Radiology, Saiseikai Utsunomiya Hospital, Tochigi, Japan
    • ,
  • Kaoru Ogawa

      Affiliations

    • Department of Otolaryngology, Keio University School of Medicine, Tokyo, Japan

Received 21 April 2006

References 

  1. Cannon CR. Hypothyroidism in head and neck cancer patients: experimental and clinical observations. Laryngoscope. 1994;104:1–21
  2. Hall EJ. Dose response relationships for normal tissues. In:  Hall EJ editors. Radiobiology for the radiologist. Philadelphia: J.B. Lippincott Co.; 1994;p. 45–73
  3. Einhorn J, Wilkholm G. Hypothyroidism after external irradiation to the thyroid region. Radiology. 1967;88:326–328
  4. Tell R, Sjodin H, Lundell G, et al. Hypothyroidism after external radiotherapy for head and neck cancer. Int J Radiat Oncol Biol Phys. 1997;39:303–308
  5. Okamura K, Ueda K, Sone H, et al. A sensitive thyroid stimulating hormone assay for screening of thyroid functional disorder in elderly Japanese. J Am Geriatr Soc. 1989;37:317–322
  6. Kumpulainen EJ, Hirvikoski PP, Virtaniemi JA, et al. Hypothyroidism after radiotherapy for laryngeal cancer. Radiother Oncol. 2000;57:97–101
  7. Posner MR, Ervin TJ, Miller D, et al. Incidence of hypothyroidism following multimodality treatment for advanced squamous cell cancer of the head and neck. Laryngoscope. 1984;94:451–454
  8. Grande C. Hypothyroidism following radiotherapy for head and neck cancer: multivariate analysis of risk factors. Radiother Oncol. 1992;25:31–36
  9. Weissler MC, Berry BW. Thyroid-stimulating hormone levels after radiotherapy and combined therapy for head and neck cancer. Head Neck. 1991;13:420–423
  10. Turner SL, Tiver KW, Boyages SC. Thyroid dysfunction following radiotherapy for head and neck cancer. Int J Radiat Oncol Biol Phys. 1995;31:279–283
  11. Hancock SL, Cox RS, Mcdougall IR. Thyroid diseases after treatment of Hodgkin's disease. N Engl J Med. 1995;325:599–605
  12. Constine LS, Donaldson SS, McDougall IR, et al. Thyroid dysfunction after radiotherapy in children with Hodgkin's disease. Cancer. 1984;53:878–883
  13. Hall EJ, Cox JD. Physical and biologic basis of radiation therapy. In:  Cox JD editors. Moss' radiation oncology rationale, technique, results. St Louis: Mosby Co St.; 1994;p. 1–66
  14. Nishiyama K, Tanaka E, Tarui Y, et al. A prospective analysis of subacute thyroid dysfunction after neck irradiation. Int J Radiat Oncol Biol Phys. 1996;34:439–444
  15. Garcia-Serra A, Amdur RJ, Morris CG, et al. Thyroid function should be monitored following radiotherapy to the low neck. Am J Clin Oncol. 2005;28:255–258
  16. Williams ED. TSH and thyroid cancer. Horm Metab Res Suppl. 1990;23:72–75

PII: S0196-0709(06)00119-0

doi: 10.1016/j.amjoto.2006.06.011

American Journal of Otolaryngology - Head and Neck Medicine and Surgery
Volume 28, Issue 1 , Pages 46-49 , January 2007

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