American Journal of Otolaryngology - Head and Neck Medicine and Surgery
Volume 28, Issue 2 , Pages 73-77 , March 2007

Serum vascular endothelial growth factor in patients with pharyngeal and laryngeal squamous cell carcinoma treated with radiotherapy

  • Iwona Gisterek, MD, PhD

      Affiliations

    • Department of Oncology Medical Academy of Wrocław, Wrocław, Poland
    • Corresponding Author InformationCorresponding author. pl. Hirszfelda 12, 53-413 Wrocław, Poland. Tel.: +48 71 3619111.
    • ,
  • Paweł Sedlaczek, PhD

      Affiliations

    • Department of Clinical Immunology Medical Academy of Wrocław, Wrocław, Poland
    • ,
  • Jan Kornafel

      Affiliations

    • Department of Oncology Medical Academy of Wrocław, Wrocław, Poland
    • ,
  • Antonina Harłoziñska-Szmyrka

      Affiliations

    • Department of Clinical Immunology Medical Academy of Wrocław, Wrocław, Poland
    • ,
  • Aleksandra Łacko, MD, PhD

      Affiliations

    • Department of Oncology Medical Academy of Wrocław, Wrocław, Poland

Received 1 May 2006

References 

  1. O-charoenrat P, Rhys-Evans P, Eccles SA. Expression of vascular endothelial growth factor family members in head and neck squamous cell carcinoma correlates with lymph node metastasis. Cancer. 2001;92:556–568
  2. Chen Z, Malhotra PS, Thomas GR, et al. Expression of proinflammatory and proangiogenic cytokines in patients with head and neck cancer. Clin Cancer Res. 1999;5:1369–1379
  3. Eisma RJ, Jeffrey BS, Spiro D, et al. Vascular endothelial growth factor expression in head and neck squamous cell carcinoma. Am J Surg. 1997;174:513–517
  4. Kaya A, Ciledag A, Gulbay BE, et al. The prognostic significance of vascular endothelial growth factor levels in sera of non-small cell lung cancer patients. Respir Med. 2004;98:632–636
  5. De Vita F, Orditura M, Lieto E, et al. Elevated perioperative serum vascular endothelial growth factor levels in patients with colon carcinoma. Cancer. 2004;100:270–278
  6. Shang ZJ, Li JR, Li ZB. Circulating levels of vascular endothelial growth factor in patients with oral squamous cell carcinoma. Int J Oral Maxillofac Surg. 2002;31:495–498
  7. Smith BD, Haffty BG, Sasaki CT. Molecular markers in head and neck squamous cell carcinoma: their biological function and prognostic significance. Ann Otol Rhinol Laryngol. 2001;110:221–228
  8. Breier G. Functions of the VEGF/VEGF receptor system in the vascular system. Semin Thromb Hemost. 2000;26:553–559
  9. Michi Y, Morita I, Amagasa T, et al. Human oral squamous cell carcinoma cell lines promote angiogenesis via expression of vascular endothelial growth factor and upregulation of KDR/flk-1 expression in endothelial cells. Oral Oncol. 2000;36:81–88
  10. Ferrara N. Vascular endothelial growth factor as a target for anticancer therapy. Oncologist. 2004;9:2–10
  11. Barbera-Guillem E, Nyhus JK, Wolford CC, et al. Vascular endothelial growth factor secretion by tumor-infiltrating macrophages essentially supports tumor angiogenesis, and IgG immune complexes potentiate the process. Cancer Res. 2002;62:7042–7049
  12. Grutzkau A, Kruger-Krasagakes S, Baumeister H, et al. Synthesis, storage, and release of vascular endothelial growth factor/vascular permeability factor (VEGF/VPF) by human mast cells: implications for the biological significance of VEGF206. Mol Biol Cell. 1998;9:875–884
  13. Homer JJ, Anyanwu K, Ell SR, et al. Serum vascular endothelial growth factor in patients with head and neck squamous cell carcinoma. Clin Otolaryngol. 1999;24:426–430
  14. Harlozinska A, Sedlaczek P, Kulpa J, et al. Vascular endothelial growth factor (VEGF) concentration in sera and tumor effusions from patients with ovarian carcinoma. Anticancer Res. 2004;24:1149–1158
  15. Dunst J, Stadler P, Becker A, et al. Tumor hypoxia and systemic levels of vascular endothelial growth factor (VEGF) in head and neck cancer. Strahlenther Onkol. 2001;177:469–473
  16. Yamamoto Y, Toi M, Kondo S, et al. Concentrations of vascular endothelial growth factor in the sera of normal controls and cancer patients. Cancer Res. 1996;2:821–826
  17. Dirix L, Vermeulen P, Prove A, et al. Elevated levels of the angiogenic cytokines basic fibroblast growth factor and vascular endothelial growth factor in sera of cancer patients. Br J Cancer. 1997;76:238–243
  18. Riedel F, Gotte K, Schwalb J, et al. Serum levels of vascular endothelial growth factor in patients with head and neck cancer. Eur Arch Otorhinolaryngol. 2000;257:332–336
  19. Chen Z, Malhotra PS, Thomas GR, et al. Expression of proinflammatory and proangiogenic cytokines in patients with head and neck cancer. Clin Cancer Res. 1999;5:1369–1379
  20. Rosen LS. Clinical experience with angiogenesis signaling inhibitors: focus on vascular endothelial growth factor (VEGF) blockers. Cancer Control. 2002;9:6–44
  21. Shang ZJ, Li JR, Li ZB. Circulating levels of vascular endothelial growth factor in patients with oral squamous cell carcinoma. Int J Oral Maxillofac Surg. 2002;31:495–498
  22. Ohta M, Konno H, Tanaka T, et al. The significance of circulating vascular endothelial growth factor (VEGF) protein in gastric cancer. Cancer Lett. 2003;192:215–225
  23. Werther K, Sorensen S, Christensen IJ, et al. Circulating vascular endothelial growth factor six months after primary surgery as a prognostic marker in patients with colorectal cancer. Acta Oncol. 2003;42:837–845
  24. Nishimura R, Nagao K, Miyayama H, et al. Higher plasma vascular endothelial growth factor levels correlate with menopause, overexpression of p53, and recurrence of breast cancer. Breast Cancer. 2003;10:120–128
  25. Karayiannakis AJ, Bolanaki H, Syrigos KN, et al. Serum vascular endothelial growth factor levels in pancreatic cancer patients with advanced and metastatic disease and poor prognosis. Cancer Lett. 2003;194:119–124
  26. Dietz A, Rudat V, Vanselow B, et al. Predictive value of serum levels of basic fibroblast growth factor, vascular endothelial growth factor and matrix metalloproteinase–2 in advanced carcinomas of the head and neck. HNO. 1999;47:695–701

PII: S0196-0709(06)00123-2

doi: 10.1016/j.amjoto.2006.06.015

American Journal of Otolaryngology - Head and Neck Medicine and Surgery
Volume 28, Issue 2 , Pages 73-77 , March 2007

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