Expression of IL-12 and T helper cell 1 cytokines in the fluid of paranasal sinus mucoceles

Kariya, Shin; Okano, Mitsuhiro; Hattori, Hisashi; Sugata, Yuji; Matsumoto, Rie; Fukushima, Kunihiro; Akagi, Hirofumi; Nishizaki, Kazunori

doi:10.1016/j.amjoto.2006.06.017

« Previous Next »American Journal of Otolaryngology - Head and Neck Medicine and Surgery
Volume 28, Issue 2 , Pages 83-86, March 2007

Expression of IL-12 and T helper cell 1 cytokines in the fluid of paranasal sinus mucoceles

Shin Kariya, MD, PhD
- Department of Otolaryngology–Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan
- Corresponding author. Department of Otolaryngology–Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama 700-8558, Japan. Tel.: +81 86 235 7307; fax: +81 86 235 7308.
Mitsuhiro Okano, MD, PhD
- Department of Otolaryngology–Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan
Hisashi Hattori, MD, PhD
- Department of Otolaryngology–Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan
Yuji Sugata, MD
- Department of Otolaryngology–Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan
Rie Matsumoto, MD
- Department of Otolaryngology–Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan
Kunihiro Fukushima, MD, PhD
- Department of Otolaryngology–Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan
Hirofumi Akagi, MD, PhD
- Department of Otolaryngology, National Hospital Organization Minami–Okayama Medical Center, Okayama, Japan
Kazunori Nishizaki, MD, PhD
- Department of Otolaryngology–Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan

Received 1 May 2006

Abstract

Objective

The objective of this study was to assess the expression of regulatory cytokines and T helper cell (Th)1/Th2 cytokines in paranasal sinus mucoceles.

Materials and methods

Fluid samples of 12 paranasal sinus mucoceles were assessed by enzyme-linked immunosorbent assay for concentrations of regulatory cytokines (interleukin [IL]-10 and IL-12), Th1 cytokines (IL-2 and interferon gamma), and Th2 cytokines (IL-4 and IL-5).

Results

IL-12 was detected in all samples, whereas IL-10 was detected in only one case. The concentration of IL-12 tended to correlate with that of interferon gamma and was significantly and positively correlated with that of IL-2.

Conclusions

Th1 cytokines and the Th1 regulatory cytokine IL-12, but not IL-10, potentially play a key role in the pathogenesis of paranasal sinus mucoceles. Together with our recent report showing that lipopolysaccharide is highly detected in mucocele fluid, the data from this study suggest that the Th1 response induced by lipopolysaccharide may affect the immunological inflammation in the epithelium of paranasal sinus mucoceles.