American Journal of Otolaryngology - Head and Neck Medicine and Surgery
Volume 28, Issue 3 , Pages 158-163 , May 2007

Osteonecrosis of the jaws due to bisphosphonate use. A review of 60 cases and treatment proposals

  • Christos Magopoulos, DDS

      Affiliations

    • Department of Oral and Maxillofacial Surgery, Aristotle University, Thessaloniki, Greece
    • Corresponding Author InformationCorresponding author. Glinou 4-Pilea, 54352 Thessaloniki, Greece. Tel.: +30 2310949711; fax: +30 2310995362.
    • ,
  • Georgios Karakinaris, DDS

      Affiliations

    • Department of Oral and Maxillofacial Surgery, Aristotle University, Thessaloniki, Greece
    • ,
  • Zisis Telioudis, DDS

      Affiliations

    • ‘Theagenio’ Cancer Istitute, Thessaloniki, Greece
    • ,
  • Konstantinos Vahtsevanos, MD, DDS

      Affiliations

    • ‘Theagenio’ Cancer Istitute, Thessaloniki, Greece
    • ,
  • Ioannis Dimitrakopoulos, MD, DDS

      Affiliations

    • Department of Oral and Maxillofacial Surgery, Aristotle University, Thessaloniki, Greece
    • ,
  • Konstantinos Antoniadis, MD, DDS

      Affiliations

    • Department of Oral and Maxillofacial Surgery, Aristotle University, Thessaloniki, Greece
    • ,
  • Sideris Delaroudis, MD

      Affiliations

    • Department of Endocrinology, Military Hospital, Thessaloniki, Greece

Received 15 May 2006

References 

  1. Ebetino FH, Francis MD, Rogers MJ, et al. Mechanisms of action of etidronate and other bisphosphonates. Rev Contemp Pharmacother. 1998;9:233–243
  2. Rogers MJ, Gordon HL, Benford FP, et al. Cellular and molecular mechanisms of action of bisphosphonates. Cancer. 2000;88:2961–2978[Suppl: Skeletal Complications of Malignancy]
  3. Marx RE. Pamidronate (AREDIA) and zoledronate (ZOMETA) induced avascular necrosis of the jaws: a growing epidemic. J Oral Maxillofac Surg. 2003;61:1115–1118
  4. Marx RE, Stern D. In: Oral and maxillo-facial pathology: a rationale for diagnosis and treatment. 1st ed. Carol Stream (Ill): Quintessence; 2003;p. 36–38
  5. Fleisch H, Reszka A, Rodan G, et al. Bisphosphonates—mechanism of action. In:  Bilezikian J,  Raisz L,  Rodan G editor. Principles of bone biology. vol. 2:Academic Press; 2002;p. 1361–1378
  6. Reszka AA, Halasy-Nagy J, Rodan GA. Nitrogen-bisphosphonates block retinoblastoma phosphorylation and cell growth by inhibiting the cholesterol biosynthetic pathway in keratinocyte model for esophageal irritation. Mol Pharmacol. 2001;59:193–202
  7. Sato M, Grasser W, Endo N, et al. Bisphosphonate action. Aledronate localization in rat bone and effects on osteoclast ultrastructure. J Clin Invest. 1991;88:2095–2105
  8. Wood J, Bonjean K, Ruetz S. Novel antiangiogenic effects of the bisphosphonate compound zoledronic acid. J Pharmacol Exp Ther. 2002;302:1055
  9. Ruggiero SL, Mehrotra B, Rosenberg TJ, et al. Osteonecrosis of the jaws associated with the use of bisphosphonates: a review of 63 cases. J Oral Maxillofac Surg. 2004;62:527–534
  10. Marx RE, Sawatari Y, Fortin M, et al. Bisphosphonate-induced exposed bone (osteonecrosis/osteopetrosis) of the jaws: risk factors, recognition, prevention, and treatment. J Oral Maxillofac Surg. 2005;63:1567–1575
  11. Key L, Ries W. Osteopetrosis. In:  Bilezikian J,  Raisz L,  Rodan G editor. Principles of bone biology. vol 2:San Francisco, CA: Academic Press; 2002;p. 1217–1227
  12. Lenz J-H, Steiner-Krammer B, Schmidt W, et al. Does avascular necrosis of jaws in cancer patients only occur following treatment with bisphosphonates?. J Cranio-Maxillofac Surg. 2005;33:395–403
  13. Ficara G, Beninati F, Rubino I, et al. Osteonecrosis of the jaws in periodontal patients with a history of bisphosphonates treatment. J Clin Periodontol. 2005;32:1123–1128
  14. Farrugia MC, Summerlin DJ, Krowiak E, et al. Osteonecrosis of the mandible or maxilla associated with the use of new generation bisphosphonates. Laryngoscope. 2006;116(1):115–120

PII: S0196-0709(06)00169-4

doi: 10.1016/j.amjoto.2006.08.004

American Journal of Otolaryngology - Head and Neck Medicine and Surgery
Volume 28, Issue 3 , Pages 158-163 , May 2007

Article Tools

* Image Usage & Resolution