American Journal of Otolaryngology - Head and Neck Medicine and Surgery
Volume 28, Issue 5 , Pages 289-293, September 2007

Intratympanic gentamicin: a 1-day protocol treatment for unilateral Meniere's disease

  • Alessandro De Stefano, MD

      Affiliations

    • Clinica ORL, Università G. d'Annunzio, Chieti-Pescara, Italy
    • ,
  • Francesco Dispenza, MD

      Affiliations

    • Clinica ORL, Università degli Studi Palermo, Palermo, Italy
    • Corresponding Author InformationCorresponding author. Via Paolo Emiliani Giudici, 37, Palermo 90127, Italy. Tel.: +393334565471; fax: +39 0523 453708.
    • ,
  • Giuseppe De Donato, MD

      Affiliations

    • Gruppo Otologico, Piacenza, Rome, Italy
    • ,
  • Antonio Caruso, MD

      Affiliations

    • Gruppo Otologico, Piacenza, Rome, Italy
    • ,
  • Abdelkader Taibah, MD

      Affiliations

    • Gruppo Otologico, Piacenza, Rome, Italy
    • ,
  • Mario Sanna, MD

      Affiliations

    • Gruppo Otologico, Piacenza, Rome, Italy

Received 30 June 2006

Abstract 

Purpose

The objective of this study was to assess the usefulness of low-dose intratympanic gentamicin administration in patients with Meniere's disease (MD).

Materials and Methods

We carried out a retrospective review of the charts of 55 patients with definite MD in accordance with the AAO-HNS (American Academy of Otolaryngology–Head and Neck Surgery) Diagnostic Scale who were treated at Gruppo Otologico (Piacenza, Rome, Italy). The treatment protocol consisted of 3 intratympanic injections of gentamicin at a 12-hour interval between each administration.

Results

Results were resumed in accordance with AAO-HNS criteria and showed complete control of vertigo spells in 60% (class A), good control in 16% (class B), moderate control in 4% (class C), poor control in 16% (class D), and no control in 4% (class E) of the patients. Audiological assessment showed unchanged thresholds in 61%, improvement in 22%, and worsening in 17% of the cases.

Conclusion

Administration of gentamicin is a good alternative to medical and surgical procedures in the treatment of intractable MD. One-day treatment allows for adequate control of vertigo attacks without compromising hearing and quality of life and with reduced costs.

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PII: S0196-0709(06)00221-3

doi:10.1016/j.amjoto.2006.09.009

American Journal of Otolaryngology - Head and Neck Medicine and Surgery
Volume 28, Issue 5 , Pages 289-293, September 2007

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