American Journal of Otolaryngology - Head and Neck Medicine and Surgery
Volume 28, Issue 6 , Pages 379-383 , November 2007

Increased expression of hypoxia-inducible factor 1α in the nasal polyps

  • Ying-Che Hsu, MD

      Affiliations

    • Department of Otolaryngology Head and Neck Surgery, Kaohsiung Medical University Hospital, Taiwan
    • ,
  • Wen-Rei Kuo, MD

      Affiliations

    • Department of Otolaryngology Head and Neck Surgery, Kaohsiung Medical University Hospital, Taiwan
    • Department of Otolaryngology Head and Neck Surgery, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Taiwan
    • ,
  • Yi-Yu Chen, MD

      Affiliations

    • Department of Pathology, Kaohsiung Medical University Hospital, Taiwan
    • ,
  • Chi-Feng Tai, MD

      Affiliations

    • Department of Otolaryngology Head and Neck Surgery, Kaohsiung Medical University Hospital, Taiwan
    • Department of Otolaryngology Head and Neck Surgery, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Taiwan
    • ,
  • Chi-Jen Tsai, PhD

      Affiliations

    • Department of Pathology, Kaohsiung Medical University Hospital, Taiwan
    • Department of Pathology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Taiwan
    • ,
  • Ling-Feng Wang, MD

      Affiliations

    • Department of Otolaryngology Head and Neck Surgery, Kaohsiung Medical University Hospital, Taiwan
    • Corresponding Author InformationCorresponding author. Department of Otolaryngology, Kaohsiung Medical University, No. 100, Tzyou 1st Road, Kaohsiung 807, Taiwan. Tel.: +886 7 3208264; fax: +886 7 3208264.

Received 5 October 2006

References 

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  2. Wittekindt C, Hess A, Bloch W, et al. Immunohistochemical expression of VEGF and VEGF receptors in nasal polyps as compared to normal turbinate mucosa. Eur Arch Otorhinolaryngol. 2002;259:294–298
  3. Matsuyama T, Nakanishi K, Hayashi T, et al. Expression of hypoxia-inducible factor-1alpha in esophageal squamous cell carcinoma. Cancer Sci. 2005;96:176–182
  4. Semenza GL. Hydroxylation of HIF-1: oxygen sensing at the molecular level.. Physiology (Bethesda). 2004;19:176–182
  5. Jiang S, Dong Z, Zhu D, et al. Local tissue hypoxia and formation of nasal polyps. Chin Med J (Engl). 2003;116:243–247
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  12. Burri P, Djonov V, Aebersold DM, et al. Significant correlation of hypoxia-inducible factor-1alpha with treatment outcome in cervical cancer treated with radical radiotherapy. Int J Radiat Oncol Biol Phys. 2003;56:494–501
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  14. Adunka O, Gstoettner W, Knecht R, et al. Expression of hypoxia inducible factor 1 alpha and Von Hippel Lindau protein in human middle ear cholesteatoma. Laryngoscope. 2003;113:1210–1215
  15. Chen D, Lin XX, Li W. The relationship between the expression of HIF-1alpha and the angiogenesis in infancy hemangioma. Zhonghua Zheng Xing Wai Ke Za Zhi. 2005;21:115–118
  16. Liu Y, Cui Y, Yu L, et al. Expression of hypoxia-inducible factor-1alpha in nasal polyps and it's correlation with vascular endothelial growth factor and inducible nitric oxide synthase. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2005;40:366–370
  17. Jiang S, Dong Z, Yang Z: Expression and the role of vascular endothelial growth factor mRNA in nasal polyps. Lin Chuang Er Bi Yan Hou Ke Za Zhi 15:339–340, 343, 2001.
  18. Guo J, Wang X, Tao G, et al. Expression of vascular endothelial growth factor and transforming growth factor-beta 1 in nasal polyps. Zhonghua Er Bi Yan Hou Ke Za Zhi. 2001;36:83–86
  19. Bhandari A, Takeuchi K, Suzuki S, et al. Increased expression of matrix metalloproteinase-2 in nasal polyps. Acta Otolaryngol. 2004;124:1165–1170
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PII: S0196-0709(06)00288-2

doi: 10.1016/j.amjoto.2006.11.004

American Journal of Otolaryngology - Head and Neck Medicine and Surgery
Volume 28, Issue 6 , Pages 379-383 , November 2007

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