American Journal of Otolaryngology - Head and Neck Medicine and Surgery
Volume 29, Issue 2 , Pages 88-93 , March 2008

Evaluation of the effect of dexamethasone in experimentally induced endolymphatic hydrops in guinea pigs

  • Fulya Ozer, MD

      Affiliations

    • Department of Otolaryngology Head and Neck Surgery, Hacettepe University Faculty of Medicine, Sıhhıye, Ankara, Turkey
    • Corresponding Author InformationCorresponding author. Reşatbey Mah. 14 sok. Kaya Apt. No: 38/1, Seyhan, 01120 Adana, Turkey. Tel.: +90 322 458 6868.
    • ,
  • Omer Faruk Unal, MD

      Affiliations

    • Department of Otolaryngology Head and Neck Surgery, Hacettepe University Faculty of Medicine, Sıhhıye, Ankara, Turkey
    • ,
  • Ahmet Atas, PhD

      Affiliations

    • Audiology Unit, Hacettepe University Faculty of Medicine, Sıhhıye, Ankara, Turkey
    • ,
  • Ozgül Tekin, PhD

      Affiliations

    • Audiology Unit, Hacettepe University Faculty of Medicine, Sıhhıye, Ankara, Turkey
    • ,
  • Arzu Sungur, MD

      Affiliations

    • Department of Pathology, Hacettepe University Faculty of Medicine, Sıhhıye, Ankara, Turkey
    • ,
  • Kıvanç Ayas, MD

      Affiliations

    • Department of Otolaryngology Head and Neck Surgery, Hacettepe University Faculty of Medicine, Sıhhıye, Ankara, Turkey

Received 2 December 2006

References 

  1. Thai-Van H, Bounaix MJ, Fraysse B. Meniere's disease: pathophysiology and treatment. Drugs. 2001;61(8):1089–1102
  2. Chi F, Liang Q, Wang Z. Effects of hyperbaric therapy on function and morphology of guinea pig cochlea with endolymphatic hydrops. Otol Neurotol. 2004;25:553–558
  3. Sennaroglu L, Sennaroglu G, Gursel B, et al. Intratympanic dexamethasone, intratympanic gentamicin, and endolymphatic sac surgery for intractable vertigo in Meniere's disease. Otolaryngol Head Neck Surg. 2001;125(5):537–543
  4. Shea J, Ge X. Dexamethasone perfusion of the labyrinth plus intravenous dexamethasone for Meniere's disease. Otolaryngol Clin North Am. 1996;29:353–358
  5. Garduno-Anaya MA, Couthino TH, Hinojosa GR, et al. Dexamethasone inner ear perfusion by intratympanic injection in unilateral Meniere's disease: a two-year prospective, placebo-controlled, double-blind, randomized trial. Otolaryngol Head Neck Surg. 2005;133(2):285–294
  6. Barrs DM, Keyser JS, Stallworth C, et al. Intratympanic steroid injections for intractable Meniere's disease. Laryngoscope. 2001;111(12):2100–2104
  7. Rarey KE, Lohuıs PJ, Ten Cate WJ. Response of the stria vascularis to corticosteroids. Laryngoscope. 1991;101:1081–1084
  8. Silverstein H, Choo D, Rosenberg S, et al. Intratympanic steroid treatment of inner ear disease and tinnitus (preliminary report). Ear Nose Throat J. 1996;75:468–488
  9. Hirvonen TP, Peltomaa M, Ylikoski J. Intratympanic and systemic dexamethasone for Meniere's disease. ORL J Otorhinolaryngol Relat Spec. 2000;62(3):117–120
  10. Liu HJ, Dong MM, Chi FL. Dexamethasone pharmacokinetics in guinea pig inner ear perilymph. ORL J Otorhinolaryngol Relat Spec. 2006;68(2):93–98
  11. Andrews JC. Laboratory experience with experimental endolymphatic hydrops. Otolaryngol Clin North Am. 1997;30:969–976
  12. Ruding PRJW, Veldman JE, VanDeelen GW. Histopathological study of experimentally induced endolymphatic hydrops with emphasis on Reissner's membrane. Arch Otorhinolaryngol. 1987;244:174–179
  13. Kimura RS. Experimental blockage of endolymphatic duct and sac and its effects on the inner ear of the guinea pig. A study on endolymphatic hydrops. Ann Otol Rhinol Laryngol. 1967;76:664–687
  14. Albers FWJ, Veldman JE, Huızıng EH. Early hair cell loss in experimental hydrops. Ann Otol Rhinol Laryngol. 1987;96:282–285
  15. Silverstein H, Isaacson JE, Olds MJ, et al. Dexamethasone inner ear perfusion for the treatment of Meniere's disease: a prospective, randomized, double-blind, crossover trial. Am J Otol. 1998;19(2):196–201
  16. Barrs DM. Intratympanic injections of dexamethasone for long-term control of vertigo. Laryngoscope. 2004;114(11):1910–1914
  17. Hillman TM, Arriaga MA, Chen DA. Intratympanic steroids: do they acutely improve hearing in cases of cochlear hydrops?. Laryngoscope. 2003;113(11):1903–1907
  18. Shea J. The role of dexamethasone or streptomycin perfusion in the treatment of Meniere's disease. Otolaryngol Clin North Am. 1997;30:1051–1059
  19. Bohmer A, Andrews JC. Maintenance of hydrostatic pressure gradients in the membranous labyrinth. Arch Otorhinolaryngol. 1989;246:65–66
  20. Andrews JC, Bohmer A, Hoffman LF. The measurement and manipulation of intralabyrinthine pressure in experimental endolymphatic hydrops. Laryngoscope. 1991;101:661–668
  21. Don M, Kwong B, Tanaka C. A diagnostic test for Meniere's disease and cochlear hydrops: impaired high-pass noise masking of auditory brainstem responses. Otol Neurotol. 2005;26:711–722

PII: S0196-0709(07)00027-0

doi: 10.1016/j.amjoto.2007.02.005

American Journal of Otolaryngology - Head and Neck Medicine and Surgery
Volume 29, Issue 2 , Pages 88-93 , March 2008

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