American Journal of Otolaryngology - Head and Neck Medicine and Surgery
Volume 29, Issue 3 , Pages 156-162 , May 2008

Nuclear localization of mammary serine protease inhibitor (MASPIN): is its impact on the prognosis in laryngeal carcinoma due to a proapoptotic effect?

  • Gino Marioni

      Affiliations

    • Department of Medical and Surgical Specialties, Section of Otolaryngology, University of Padova, Padova, Italy
    • Corresponding Author InformationCorresponding author. Department of Medical and Surgical Specialties, Section of Otolaryngology, University of Padova, Via Giustiniani 2, 35100 Padova, Italy. Tel.: +39 49 8218626; fax: +39 49 8752266.
    • ,
  • Luciano Giacomelli

      Affiliations

    • Department of Medical/Diagnostic Sciences and Special Therapies, Section of Anatomic Pathology, University of Padova, Padova, Italy
    • ,
  • Emiliano D'Alessandro

      Affiliations

    • Department of Medical/Diagnostic Sciences and Special Therapies, Section of Anatomic Pathology, University of Padova, Padova, Italy
    • ,
  • Rosario Marchese-Ragona

      Affiliations

    • Department of Medical and Surgical Specialties, Section of Otolaryngology, University of Padova, Padova, Italy
    • ,
  • Claudia Staffieri

      Affiliations

    • Department of Medical and Surgical Specialties, Section of Otolaryngology, University of Padova, Padova, Italy
    • ,
  • Silvia M. Ferraro

      Affiliations

    • Department of Medical and Surgical Specialties, Section of Otolaryngology, University of Padova, Padova, Italy
    • ,
  • Alberto Staffieri

      Affiliations

    • Department of Medical and Surgical Specialties, Section of Otolaryngology, University of Padova, Padova, Italy
    • ,
  • Stella Blandamura

      Affiliations

    • Department of Medical/Diagnostic Sciences and Special Therapies, Section of Anatomic Pathology, University of Padova, Padova, Italy

Received 2 January 2007

References 

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  2. Lockett J, Yin S, Li X, et al. Tumor suppressive maspin and epithelial homeostasis. J Cell Biochem. 2006;97:651–660
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  4. Koornstra JJ, Rijcken FEM, de Jong S, et al. Assessment of apoptosis by M30 immunoreactivity and the correlation with morphological criteria in normal colorectal mucosa, adenomas and carcinomas. Histopathology. 2004;44:9–17
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  8. Marioni G, Blandamura S, Giacomelli L, et al. Nuclear expression of maspin is associated with a lower recurrence rate and a longer disease free interval after surgery for squamous cell carcinoma of the larynx. Histopathology. 2005;46:576–582
  9. Ueno T, Toi M, Linder S. Detection of epithelial cell death in the body by cytokeratin 18 measurement. Biomed Pharmacother. 2005;59:S359–S362
  10. Latha K, Zhang W, Cella N, et al. Maspin mediates increased tumour cell apoptosis upon induction of the mitochondrial permeability transition. Mol Cell Biol. 2005;25:1737–1748
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  14. Cuello-Carrion FD, Ciocca DR. Improved detection of apoptotic cells using a modified in situ TUNEL technique. J Histochem Cytochem. 1999;47:837–839
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  16. Grassi A, Susca M, Ferri S, et al. Detection of the M30 neoepitope as a new tool to quantify liver apoptosis timing and patterns of positivity on frozen and paraffin-embedded sections. Am J Clin Pathol. 2004;121:211–219
  17. Leers MPG, Kölgen W, Björklund V, et al. Immunocytochemical detection and mapping of a cytokeratin 18 neo-epitope exposed during early apoptosis. J Pathol. 1999;187:567–572
  18. Backus HHJ, Van Groeningen CJ, Vos W, et al. Differential expression of cell cycle and apoptosis related proteins in colorectal mucosa, primary colon tumours and liver metastases. J Clin Pathol. 2002;55:206–211
  19. Liu J, Yin S, Reddy N, et al. Bax mediates the apoptosis-sensitizing effect of maspin. Cancer Res. 2004;64:1703–1711
  20. Chen EI, Florens L, Axelrod FT, et al. Maspin alters the carcinoma proteome. FASEB J. 2005;19:1123–1124
  21. Jiang N, Meng Y, Zhang S, et al. Maspin sensitizes breast carcinoma cells to induced apoptosis. Oncogene. 2002;21:4089–4098
  22. Marioni G, D'Alessandro E, Giacomelli L, et al. Maspin nuclear localization is related to reduced density of tumour-associated microvessels in laryngeal carcinoma. Anticancer Res. 2006;26:4927–4932
  23. Sood AK, Fletcher MS, Gruman LM, et al. The paradoxical expression of maspin in ovarian carcinoma. Clin Cancer Res. 2002;8:2924–2932
  24. Mohsin SK, Zhang M, Clark GM, et al. Maspin expression in invasive breast cancer: association with other prognostic factors. J Pathol. 2003;199:432–435
  25. Beltran A, Parikh S, Liu Y, et al. Re-activation of a dormant tumor suppressor gene maspin by designed transcription factors. Oncogene. 2007;26:2791–2798

☆ This research was partially founded by the University of Padova (Italy), project code 60A07-7352/06.

PII: S0196-0709(07)00061-0

doi: 10.1016/j.amjoto.2007.04.010

American Journal of Otolaryngology - Head and Neck Medicine and Surgery
Volume 29, Issue 3 , Pages 156-162 , May 2008

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