American Journal of Otolaryngology - Head and Neck Medicine and Surgery
Volume 29, Issue 3 , Pages 163-166 , May 2008

Acyclovir plus steroid vs steroid alone in the treatment of Bell's palsy

  • Seung Geun Yeo, MD

      Affiliations

    • Department of Otolaryngology, College of Medicine, Kyung Hee University, Seoul, South Korea
    • Corresponding Author InformationCorresponding author. Department of Otolaryngology, College of Medicine, Kyung Hee University, #1 Hoegi-dong, dongdaemun-gu, Seoul 130-702, South Korea. Tel.: +82 2 958 8474; fax: +82 2 958 8470.
    • ,
  • Young Chan Lee, MD

      Affiliations

    • Department of Otolaryngology, College of Medicine, Kyung Hee University, Seoul, South Korea
    • ,
  • Dong Choon Park, MD

      Affiliations

    • Department of Obstetric and Gynecology, College of Medicine, Catholic University, Suwon, South Korea
    • ,
  • Chang Il Cha, MD

      Affiliations

    • Department of Otolaryngology, College of Medicine, Kyung Hee University, Seoul, South Korea

Received 16 February 2007

References 

  1. Yanagihara N. Incidence of Bell's palsy. Ann Otol Rhinol Laryngol. 1988;97:3–4
  2. Peitersen E. The natural history of Bell's palsy. Am J Otol. 1982;4:107–111
  3. Austin JR, Peskind SP, Austin SG, et al. Idiopathic facial nerve paralysis: a randomized, double-blind, controlled study of placebo versus prednisone. Laryngoscope. 1993;103:1326–1333
  4. Furuta Y, Fukuda S, Chida E, et al. Reactivation of herpes simplex virus type I in patients with Bell's palsy. J Med Virol. 1998;54:162–166
  5. Adour KK, Ruboyianes JM, Von Doersten PG, et al. Bell's palsy treatment with acyclovir and prednisone compared with prednisone alone: a double-blind, randomized, controlled trial. Ann Otol Rhinol Laryngol. 1996;105:371–378
  6. Hato N, Martsumoto S, Kisaki H, et al. Efficacy of early treatment of Bell's palsy with oral acyclovir and prednisolone. Otol Neurotol. 2003;24:948–951
  7. House J, Brackmann DE. Facial nerve grading system. Otolaryngol Head Neck Surg. 1985;93:146–147
  8. Adour KK, Wingerd J, Bell DN. Prednisone for idiopathic facial paralysis (Bell's palsy). N Engl J Med. 1972;287:1268–1272
  9. May M, Wette R, Hardin WB. The use of steroid in Bell's palsy: a prospective controlled study. Laryngoscope. 1976;86:1111–1122
  10. Wolf SM, Wagner JH, Davidson S. Treatment of Bell's palsy with prednisone: a prospective randomized study. Neurology. 1978;28:158–161
  11. Murakami S, Mizobuchi M, Nakashiro Y, et al. Bell's palsy and herpes simplex virus: identification of viral DNA in endoneural fluid and muscle. Ann Intern Med. 1996;124:27–30
  12. Thomas L, Walter B, Daniel B. Bell's palsy and herpes simplex virus: fact or mystery?. Otol Neurotol. 2005;26:109–113
  13. Wagstaff AJ, Faulds D, Goa KL. Acyclovir. A reappraisal of its antiviral activity. Pharmacokinetic properties and therapeutic efficacy. Drugs. 1994;47:153–205
  14. Balliet R. Facial paralysis and other neuromuscular dysfunctions of the peripheral nervous system. In:  Payton OD editors. Manual of physical therapy. New York: Churchill Livingstone; 1989;p. 175
  15. Brach JS, VanSwearingen JM, Lenert J, et al. Facial neuromuscular retraining for oral synkinesis. Plast Reconstr Surg. 1997;99:1922–1933
  16. Hato N, Yamada H, Kohno H, et al. Valacyclovir and prednisolone treatment for Bell's palsy: a multicenter, randomized, placebo-controlled study. Otol Neurotol. 2007;28:408–413

PII: S0196-0709(07)00063-4

doi: 10.1016/j.amjoto.2007.05.001

American Journal of Otolaryngology - Head and Neck Medicine and Surgery
Volume 29, Issue 3 , Pages 163-166 , May 2008

Article Tools