American Journal of Otolaryngology - Head and Neck Medicine and Surgery
Volume 29, Issue 4 , Pages 223-229 , July 2008

The effects of sulfurous-arsenical-ferruginous thermal water nasal irrigation in wound healing after functional endoscopic sinus surgery for chronic rhinosinusitis: a prospective randomized study

  • Alberto Staffieri, MD

      Affiliations

    • Department of Medical and Surgical Specialties, Section of Otolaryngology, University of Padova, Padua, Italy
    • Corresponding Author InformationCorresponding author. Department of Medical and Surgical Specialties, Section of Otolaryngology, Via Giustiniani 2, 35100 Padua, Italy. Tel.: +39 049 8212010; fax: +39 049 8752266.
    • ,
  • Filippo Marino, MD

      Affiliations

    • Department of Medical/Diagnostic Sciences and Special Therapies, Section of Anatomic Pathology, University of Padova, Padua, Italy
    • ,
  • Claudia Staffieri, MD

      Affiliations

    • Department of Medical and Surgical Specialties, Section of Otolaryngology, University of Padova, Padua, Italy
    • ,
  • Luciano Giacomelli, BD

      Affiliations

    • Department of Medical/Diagnostic Sciences and Special Therapies, Section of Anatomic Pathology, University of Padova, Padua, Italy
    • ,
  • Emiliano D'Alessandro, MD

      Affiliations

    • Department of Medical/Diagnostic Sciences and Special Therapies, Section of Anatomic Pathology, University of Padova, Padua, Italy
    • ,
  • Silvia Maria Ferraro, MD

      Affiliations

    • Department of Medical and Surgical Specialties, Section of Otolaryngology, University of Padova, Padua, Italy
    • ,
  • Umberto Fedrazzoni, MD

      Affiliations

    • Levico Spa, Levico Terme, Trento, Italy
    • ,
  • Gino Marioni, MD

      Affiliations

    • Department of Medical and Surgical Specialties, Section of Otolaryngology, University of Padova, Padua, Italy

Received 31 January 2007

References 

  1. Berger G, Kattan A, Bernheim J, et al. Polypoid mucosa with eosinophilia and glandular hyperplasia in chronic sinusitis: a histopathological and immunohistochemical study. Laryngoscope. 2002;112:738–745
  2. Brown CL, Graham SM. Nasal irrigation: good or bad?. Curr Opin Otolaryngol Head Neck Surg. 2004;12:9–13
  3. Rabago D, Pasic T, Zgierska A, et al. The efficacy of hypertonic saline nasal irrigation for chronic sinonasal symptoms. Otolaryngol Head Neck Surg. 2005;133:3–8
  4. Talbot AR, Herr TM, Parsons DS. Mucociliary clearance and buffered hypertonic saline solution. Laryngoscope. 1997;107:500–503
  5. Inanli S, Ozturk O, Korkmaz M, et al. The effects of topical agents of fluticasone propionate, oxymetazoline, and 3% and 0.9% sodium chloride solutions on mucociliary clearance in the therapy of acute bacterial rhinosinusitis in vivo. Laryngoscope. 2002;12:320–325
  6. Miwa M, Matsunaga M, Nakajima N, et al. Hypertonic saline alters electrical barrier of the airway epithelium. Otolaryngol Head Neck Surg. 2007;136:62–66
  7. Unal M, Goruc K, Ozcan C. Ringer-lactate solution versus isotonic saline solution on mucociliary function after nasal septal surgery. J Laryngol Otol. 2001;115:796–797
  8. Staffieri A, Abramo A. Sulphurous-arsenical-ferruginous (thermal) water inhalations reduce nasal respiratory resistance and improve mucociliary clearance in patients with chronic sinonasal disease: preliminary outcomes. Acta Otolaryngol (Stockh). 2007;127:613–617
  9. Gualtierotti R, Rastelli A, Parise G. Ricerche di farmacologia sperimentale dell'arsenico effettuate sull'acqua minerale “Levico-Forte” somministrata per os. Med Term Climatol. 1991;85-86:5–16
  10. Sobol SE, Fukakusa M, Christodoulopoulos P, et al. Inflammation and remodeling of the sinus mucosa in children and adults with chronic sinusitis. Laryngoscope. 2003;113:410–414
  11. Watelet JB, Demetter P, Claeys C, et al. Neutrophil-derived metalloproteinase-9 predicts healing quality after sinus surgery. Laryngoscope. 2005;115:56–61
  12. Watelet JB, Demetter P, Claeys C, et al. Wound healing after paranasal sinus surgery: neutrophilic inflammation influences the outcome. Histopathology. 2006;48:174–181
  13. Scavuzzo MC, Fattori B, Ruffoli R, et al. Inflammatory mediators and eosinophilia in atopic and non-atopic patients with nasal polyposis. Biomed Pharmacother. 2005;59:323–329
  14. Bryson JM, Tasca RA, Rowe-Jones JM. Local and systemic eosinophilia in patients undergoing endoscopic sinus surgery for chronic rhinosinusitis with and without polyposis. Clin Otolaryngol. 2003;28:55–58
  15. Kitapci F, Muluk NB, Atasoy P, et al. Role of mast and goblet cells in the pathogenesis of nasal polyps. J Otolaryngol. 2006;35:122–132

PII: S0196-0709(07)00109-3

doi: 10.1016/j.amjoto.2007.07.002

American Journal of Otolaryngology - Head and Neck Medicine and Surgery
Volume 29, Issue 4 , Pages 223-229 , July 2008

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