American Journal of Otolaryngology - Head and Neck Medicine and Surgery
Volume 29, Issue 4 , Pages 242-249 , July 2008

Donor bone marrow in laryngeal transplantation: results of a rat study

  • Samir S. Khariwala, MD

      Affiliations

    • Head and Neck Institute, Cleveland Clinic Foundation, Cleveland, OH, USA
    • Corresponding Author InformationCorresponding author. 758 Waymarket Drive, Ann Arbor, MI, 48103, USA.
    • ,
  • Olivia Dan, BS

      Affiliations

    • Head and Neck Institute, Cleveland Clinic Foundation, Cleveland, OH, USA
    • ,
  • Robert R. Lorenz, MD

      Affiliations

    • Head and Neck Institute, Cleveland Clinic Foundation, Cleveland, OH, USA
    • ,
  • Aleksandra Klimczak, PhD

      Affiliations

    • Department of Plastic Surgery, Cleveland Clinic Foundation, Cleveland, OH, USA
    • ,
  • Maria Siemionow, MD, PhD

      Affiliations

    • Department of Plastic Surgery, Cleveland Clinic Foundation, Cleveland, OH, USA
    • ,
  • Marshall Strome, MD, MS

      Affiliations

    • Head and Neck Institute, Cleveland Clinic Foundation, Cleveland, OH, USA

Received 9 August 2007

References 

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  13. Tai CY, France MA, Strande LF, et al. An extraperitoneal isolated vascularized bone marrow transplant model in the rat. Transplantation. 2003;75:1591–1603
  14. Nelson M, Dan O, Strome M. Evaluation of PTH as a functional biological marker of rat laryngeal transplant rejection. Laryngoscope. 2003;113:1483–1486
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  16. Gozzo JJ, Wood ML, Monaco AP. Use of allogeneic, homozygous bone marrow cells for the induction of specific immunologic tolerance in mice treated with antilymphocyte serum. Surg Forum. 1970;21:281–284
  17. Thomas JM, Carver FM, Foil MB, et al. Renal allograft tolerance induced with ATG and donor bone marrow in outbred rhesus monkeys. Transplantation. 1983;36:104–106
  18. Starzl TE, Murase N, Abu-Elmadg K, et al. Tolerogenic immunosuppression for organ transplantation. Lancet. 2003;361:1502–1510
  19. Ramsamooj R, Llull R, Patel MP, et al. Mechanisms of alloimmune tolerance associated with mixed chimerism induced by vascularized bone marrow transplants. Cell Transplantation. 2002;11:683–693
  20. Suzuki H, Patel N, Matthews M, et al. Vascularized bone marrow transplantation: a new surgical approach using isolated femoral bone/bone marrow. J Surg Res. 2000;89:176–183
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  22. Siemionow M, Ortak T, Izycki D, et al. Induction of tolerance in composite-tissue allografts. Transplantation. 2002;74:1211–1217
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☆ Presented at the Triological Society Annual Meeting (COSM), April 2007, San Diego, CA.

☆☆ This work was supported in part by a research grant from the Triological Society. In addition, support was in part received from an internal Research Protocol Committee grant from The Cleveland Clinic Foundation. This study was performed in accordance with the PHS Policy on Human Case and Use of Laboratory Animals, the NIH guide for the Care and Use of Laboratory Animals, and Animal Welfare Act (7 U.S.C et seq.). The animal protocol was approved by the Institutional Animal Care and Use Committee of The Cleveland Clinic Foundation.

PII: S0196-0709(07)00118-4

doi: 10.1016/j.amjoto.2007.08.007

American Journal of Otolaryngology - Head and Neck Medicine and Surgery
Volume 29, Issue 4 , Pages 242-249 , July 2008

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