American Journal of Otolaryngology - Head and Neck Medicine and Surgery
Volume 29, Issue 4 , Pages 255-261 , July 2008

A single topical agent is clinically equivalent to the combination of topical and oral antibiotic treatment for otitis externa

  • Peter S. Roland, MD

      Affiliations

    • Department of Otolaryngology Head-Neck Surgery, University of Texas, Southwestern Medical School, Dallas TX, USA.
    • Corresponding Author InformationCorresponding author. Department of Otolaryngology Head-Neck Surgery, University of Texas, Southwestern Medical School, Dallas TX 75235-9035, USA.
    • ,
  • Barbara P. Belcher, MD

      Affiliations

    • Protocare Trials, San Antonio Center for Clinical Research and Child Care Associates, San Antonio TX, USA
    • ,
  • Robert Bettis, MD

      Affiliations

    • Family Medicine, University of Washington, Edmonds WA, USA
    • ,
  • Reynaldo L. Makabale, MD

      Affiliations

    • General Pediatrics, Los Angeles CA, USA
    • ,
  • Peter J. Conroy, PhD JD

      Affiliations

    • Otic/Nasal Products Development, Alcon Research, Ltd, Fort Worth TX, USA
    • ,
  • G. Michael Wall, PhD

      Affiliations

    • Otic/Nasal Products Development, Alcon Research, Ltd, Fort Worth TX, USA
    • ,
  • Sheryl Dupre, BS

      Affiliations

    • Otic/Nasal Products Development, Alcon Research, Ltd, Fort Worth TX, USA
    • ,
  • Susan Potts, MS

      Affiliations

    • Otic/Nasal Products Development, Alcon Research, Ltd, Fort Worth TX, USA
    • ,
  • Gail Hogg, BS

      Affiliations

    • Otic/Nasal Products Development, Alcon Research, Ltd, Fort Worth TX, USA
    • ,
  • Kaye Weber, MS

      Affiliations

    • Department of Otolaryngology Head-Neck Surgery, University of Texas, Southwestern Medical School, Dallas TX, USA.
    • ,
  • The Cipro HC Study Group

Received 9 May 2007

References 

  1. Halpern MT, Palmer CS, Seidlin M. Treatment patterns for otitis externa. J Am Board Fam Pract. 1999;12:1–7
  2. Goldblatt EL, Dohar J, Nozza RJ, et al. Topical ofloxacin versus systemic amoxicillin/clavulanate in purulent otorrhea in children with tympanostomy tubes. Int J Pediatr Otorhinolaryngol. 1998;46(1-2):91–101
  3. Ghosh S, Panarese A, Parker AJ, et al. Quinolone ear drops for chronic otitis media. They are safer and more effective than aminoglycosides. BMJ. 2000;321(7254):126–127
  4. Hannley MT, Denneny JC, Holzer SS. Use of ototopical antibiotics in treating 3 common ear diseases. Otolaryngol Head Neck Surg. 2000;122(6):934–940
  5. Supiyaphun P, Kerekhanjanarong V, Koranasophonepun J, et al. Comparison of ofloxacin otic solution with oral amoxicillin plus chloramphenicol ear drop in treatment of chronic suppurative otitis media with acute exacerbation. J Med Assoc Thai. 2000;83(1):61–68
  6. Gydé MC, Norris D, Kavalec EC. The weeping ear: clinical re-evaluation of treatment. J Int Med Res. 1982;10:333–340
  7. Wadsten C-J, Bertilsson CA, Sieradzki H, et al. A randomized clinical trial of two topical preparations (franmycitin/gramicidin and oxytetracycline/hydrocortisone with polymycin B) in the treatment of external otitis. Arch Otorhinolaryngol. 1985;242:135–139
  8. Browning GG, Gatehouse S, Calder IT. Medical management of active chronic otitis media: a controlled study. J Laryngol Otol. 1988;102(6):491–495
  9. Crowther JA, Simpson D. Medical treatment of chronic otitis media: steroid or antibiotic with steroid ear drops?. Clin Otolaryngol. 1991;16:142–144
  10. Tong MCF, Woo JKS, van Hasselt CA. A double-blind comparative study of ofloxacin otic drops versus neomycin-polymyxin B-hydrocortisone otic drops in the medical treatment of chronic suppurative otitis media. J Laryngol Otol. 1996;110:309–314
  11. Welling DB, Forrest LA, Goll F. Safety of ototopical antibiotics. Laryngoscope. 1995;105:472–474
  12. Hester TO, Jones RO, Archer SM, et al. Prophylactic antibiotic drops after tympanostomy tube placement. Arch Otolaryngol Head Neck Surg. 1995;121:445–448
  13. Pistorius B, Westberry K, Drehobl M, et al. Otitis Externa Study Group Prospective, randomized, comparative trial of ciprofloxacin otic drops, with or without hydrocortisone, vs. polymyxin B-neomycin-hydrocortisone otic suspension in the treatment of acute diffuse otitis externa. Infect Dis Clin Pract. 1999;8(8):387–395
  14. Smith RB, Moodie J. Comparative efficacy and tolerability of two antibacterial/anti-inflammatory formulations (‘Otomize’ spray and ‘Otosporin’ drops) in the treatment of otitis externa in general practice. Curr Med Res Opin. 1990;11:661–667
  15. Jones RN, Milazzo J, Seidlin M. Ofloxacin otic solution for treatment of otitis externa in children and adults. Arch Otolaryngol Head Neck Surg. 1997;123:1193–1200
  16. McCoy SI, Zell ER, Besser RE. Antimicrobial prescribing for otitis externa in children. Pediatr Infect Dis J. 2004;23(2):181–183
  17. Rowlands S, Devalia H, Smith C, et al. Otitis externa in UK general practice: a survey using the UK General Practice Research Database. Br J Gen Pract. 2001;51(468):533–538
  18. Rosenfeld RM, Brown L, Cannon CR, et al. American Academy of Otolaryngology–Head Neck Surgery Foundation. Clinical practice guideline: acute otitis externa. Otolaryngol Head Neck Surg. 2006;134(4 Suppl):S4–S23
  19. Altuntas A, Aslan A, Eren N, et al. Susceptibility of microorganisms isolated from chronic suppurative otitis media to ciprofloxacin. Eur Arch Otorhinolarygol. 1996;253:364–366
  20. Wiedemann B, Grimm H. Susceptibility to antibiotics: Species incidence and trends. In:  Lorian V editors. Antibiotics in Laboratory Medicine. Baltimore: Williams and Wilkins; 1996;p. 900–1168
  21. Brun J. Patient compliance with once-daily and twice-daily oral formulations of 5-isosorbide mononitrate: a comparative study. J Int Med Res. 1994;22:266–272
  22. Kruse W, Eggert-Kruse W, Rampmaier J, et al. Dosage frequency and drug-compliance behaviour—a comparative study on compliance with a medication to be taken twice or four times daily. Eur J Clin Pharmacol. 1991;41(6):589–592
  23. Roland PS. Clinical ototoxicity of topical antibiotic drops. Otolaryngol Head Neck Surg. 1994;110:598–602
  24. Rackover Y, Keywan K, Rosen G. Safety of topical ear drops containing ototoxic antibiotics. J Otolaryngol. 1997;26(3):194–196
  25. Podoshin L, Fradis M, Ben-David J. Ototoxicity of ear drops in patients suffering from chronic otitis media. J Laryngol Otol. 1989;103:46–50
  26. Ruben RJ. Efficacy of ofloxacin and other otic preparations for otitis externa. Pediatr Infect Dis J. 2001;20(1):109–110
  27. Chyský V, Kapila K, Hullmann R, et al. Safety of ciprofloxacin in children: worldwide clinical experience based on compassionate use. emphasis on joint evaluation. Infection. 1991;19(4):289–296
  28. Heaton JD, Hackett RB. Systemic and ocular safety of ciprofloxacin ophthalmic solution (Ciloxan) in immature animals. J Toxicol Cutan Ocul Toxicol. 1993;12(4):273–283

☆ This research was supported by institutional grants to each investigator from Alcon Research, Ltd.

PII: S0196-0709(07)00141-X

doi: 10.1016/j.amjoto.2007.09.002

American Journal of Otolaryngology - Head and Neck Medicine and Surgery
Volume 29, Issue 4 , Pages 255-261 , July 2008

Article Tools

* Image Usage & Resolution