American Journal of Otolaryngology - Head and Neck Medicine and Surgery
Volume 29, Issue 5 , Pages 300-304 , September 2008

Histopathologic changes in guinea pig mastoid mucosa after topical mitomycin C application followed by mastoidectomy

  • Levent Ozturk, MD

      Affiliations

    • Department of Otorhinolaryngology, Kahramanmaraş Government Hospital, Kahramanmaraş, Turkey
    • ,
  • Irfan Kaygusuz, MD

      Affiliations

    • Department of Otorhinolaryngology, Firat University Medical Faculty, Elazig, Turkey
    • ,
  • Nusret Akpolat, MD

      Affiliations

    • Department of Pathology, Firat University Medical Faculty, Elazig, Turkey
    • ,
  • Erol Keles, MD

      Affiliations

    • Department of Otorhinolaryngology, Firat University Medical Faculty, Elazig, Turkey
    • ,
  • Turgut Karlidag, MD

      Affiliations

    • Department of Otorhinolaryngology, Firat University Medical Faculty, Elazig, Turkey
    • ,
  • Hayrettin Cengiz Alpay, MD

      Affiliations

    • Department of Otorhinolaryngology, Firat University Medical Faculty, Elazig, Turkey
    • Corresponding Author InformationCorresponding author. Department of Otorhinolaryngology, Firat University, Medical Faculty, 23200 Elazig, Turkey. Tel.: + 90 424 233 35 55; fax: +90 424 238 80 96.
    • ,
  • Sinasi Yalcin, MD

      Affiliations

    • Department of Otorhinolaryngology, Firat University Medical Faculty, Elazig, Turkey

Received 3 May 2007

References 

  1. Daly KA. Epidemiology of otitis media. Otolaryngol Clin North Am. 1991;24:775–786
  2. Parikh AA, Brookes GB. Subtotal petrosectomy with external canal overclosure in the management of chronic suppurative otitis media. J Laryngol Otol. 1994;108:197–201
  3. Palva T. Obliteration of the mastoid cavity and reconstruction of the canal wall. In:  Gibb AG,  Smith MF editor. International Medical Reviews: Otolaryngology I: Otology. London: Butterworths; 1982;p. 19–29
  4. Miyamura S, Shigeno N, Matsui S, et al. The biological studies on mitomycin, I: antibacterial activities of mitomycin derivatives. J Antibiot. 1967;20:72–76
  5. Bradner WT. Mitomycin C: a clinical update. Cancer Treat Rev. 2001;27:35–50
  6. Ribeiro FAQ, Guaraldo L, Borges JP, et al. Clinical and histological healing of surgical wounds treated with mitomycin-C. Laryngoscope. 2004;114:148–152
  7. Nadol JB. Causes of failure of mastoidectomy for chronic otitis media. Laryngoscope. 1985;95:410–413
  8. Correa AJ, Reinisch L, Sanders DL, et al. Inhibition of subglottic stenosis with mitomycin-C in the canine model. Ann Otol Rhinol Laryngol. 1999;108:1053–1060
  9. Eliashar R, Eliachar I, Esclamado R, et al. Can topical mitomycin prevent laryngotracheal stenosis?. Laryngoscope. 1999;109:1594–1600
  10. Spector JE, Werkhaven JA, Spector NC, et al. Preservation of function and histologic appearance in the injured glottis with topical mitomycin-C. Laryngoscope. 1999;109:1125–1129
  11. Schuknecht HF. In: Pathology of the Ear. London: Saunders Co; 1967;p. 5–26
  12. Brown MT, Montgomery WW. Microbiology of tracheal granulation tissue associated with silicone airway protheses. Ann Otol Rhinol Laryngol. 1996;105:624–627
  13. Meyerhoff WL, Kim CS, Paparella MM. Pathology of chronic otitis media. Ann Otol Rhinol Laryngol. 1978;87:749–760
  14. Taylor M, McMinn RMH. Preliminary observations on the histopathology of wet mastoid cavities. J Laryngol Otol. 1966;60:42–54
  15. Sugar A. Who should receive mitomycin-C after pterygium surgery?. Ophthalmology. 1992;99:1645–1646
  16. Ward RF, April MM. Mitomycin-C in the treatment of tracheal cicatrix after tracheal reconstruction. Int J Pediatr Otorhinolaryngol. 1998;44:221–226
  17. McLeod IK, Brooks DB, Mair EA. Revision choanal atresia repair. Int J Pediatr Otorhinolaryngol. 2003;67:517–524
  18. Rombaux P, de Toeuf C, Hamoir M, et al. Transnasal repair of unilateral choanal atresia. Rhinology. 2003;41:31–36
  19. Singh G, Wilson MR, Foster CS. Mitomycin eye drops as treatment for pterygium. Ophthalmology. 1988;95:813–821
  20. Rubinfeld RS, Pfister RR, Stein RM, et al. Serous complications of topical mitomycin-C after pterygium surgery. Ophthalmology. 1992;99:1647–1654
  21. Babu SC, Kartush JM, Patni A. Otologic effects of topical mitomycin C: phase I-evaluation of ototoxicity. Otol Neurotol. 2005;26:140–144

PII: S0196-0709(07)00144-5

doi: 10.1016/j.amjoto.2007.09.005

American Journal of Otolaryngology - Head and Neck Medicine and Surgery
Volume 29, Issue 5 , Pages 300-304 , September 2008

Article Tools

* Image Usage & Resolution