American Journal of Otolaryngology - Head and Neck Medicine and Surgery
Volume 30, Issue 1 , Pages 8-16 , January 2009

Study on neural stem cell transplantation into natural rat cochlea via round window

  • Yong Fu, MD, PhD

      Affiliations

    • Department of Otorhinolaryngology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hang Zhou, People's Republic of China
    • Department of Otorhinolaryngology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China
    • ,
  • Shenqing Wang, MD

      Affiliations

    • Department of Otorhinolaryngology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hang Zhou, People's Republic of China
    • ,
  • Yingpeng Liu, MD

      Affiliations

    • Department of Otorhinolaryngology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China
    • ,
  • Jianting Wang, MD, PhD

      Affiliations

    • Department of Otorhinolaryngology Head and Neck Surgery, Beijing, Chaoyang Hospital, Capital Medical University, Beijing, People's Republic of China
    • ,
  • Guopeng Wang, MD

      Affiliations

    • Department of Otorhinolaryngology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China
    • ,
  • Qingguo Chen, MD

      Affiliations

    • Department of Otorhinolaryngology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China
    • ,
  • Shusheng Gong, MD, PhD

      Affiliations

    • Department of Otorhinolaryngology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China
    • Department of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otorhinolaryngology-Head & Neck Surgery (CMU), Ministry of Education, Beijing, People's Republic of China
    • Corresponding Author InformationCorresponding author. Department of Otorhinolaryngology Head and Neck Surgery, Beijing, Tongren Hospital, Capital Medical University. Beijing 100730, People's Republic of China. Tel.: +86 13911068366.

Received 3 October 2007

References 

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  2. Iguchi F, Nakagawa T, Tateya I, et al. Trophic support of mouse inner ear by neural stem cell transplantation. Neuroreport. 2003;14:77–80
  3. Tateya I, Nakagawa T, Iguchi F, et al. Fate of neural stem cells grafted into injured inner ears of mice. Neuroreport. 2003;14(13):1677–1681
  4. Tamura T, Nakagawa T, Iguchi F, et al. Transplantation of neural stem cells into the modiolus of mouse cochleae injured by cisplatin. Acta Otolaryngol. 2004;551:65–68
  5. Hu Z, Wei D, Johansson CB, et al. Survival and neural differentiation of adult neural stem cells transplanted into the mature inner ear. Exp Cell Res. 2005;302(1):40–47
  6. Fu Y, Gong SS, Liu YP, et al. An experimental study of effects of recombinant adenovirus with GFP transfer into neural stem cells. J Audiol Speech Pathol. 2007;15(5):379–382
  7. Mitchell A, Miller JM, Finger PA, et al. Effects of chronic high-rate electrical stimulation on the cochlea and eighth nerve in the deafened guinea pig. Hear Res. 1997;105:30–43
  8. Fu Y, Gong SS, Xue QH, et al. Culture identification and label of embryonic rat neural stem cells. J Clin Otorhinolaryngol Head Neck Surg. 2007;21(4):172–175
  9. Ding DL, Li M, Jiang SC. In: Morphology of the inner ear [M]. Heilongjiang. Haerbing (China): Science and Technology Publishing House; 2001;p. 24–28
  10. Clarke DL, Johansson CB, Wilbertz J, et al. Generalized potential of adult neural stem cells. Science. 2000;288:1660–1663
  11. Gage FH. Mammalian neural stem cells. Science. 2000;287:1433–1438
  12. Raphael Y, Frisancho JC, Roessler BJ. Adenoviral-mediated gene transfer into guinea pig cochlear cells in vivo. Neurosci Lett. 1996;207:137–141
  13. Lalwani A, Walsh B, Reilly P, et al. Long-term in vivo cochlear transgene expression mediated by recombinant adeno-associated virus. Gene Ther. 1998;5:277–281
  14. Stöver T, Yagi M, Raphael Y. Cochlear gene transfer: round window versus cochleostomy inoculation. Hear Res. 1999;136:124–130
  15. Thorne M, Salt AN, De Mott JE, et al. Cochlear fluid space dimensions for six species derived from reconstructions of three-dimensional magnetic resonance images. Laryngoscope. 1999;109:1661–1668
  16. Salt AN, Ma Y. Quantification of solute entry into cochlear perilymph through the round window membrane. Hear Res. 2001;154:88–97
  17. Rubel EW, Fritzsch B. Auditory system development: primary auditory neurons and their targets. Annu Rev Neurosci. 2002;25:51–101
  18. Qun LX, Pirvola U, Saarma M, et al. Neurotrophic factors in the auditory periphery. Ann N Y Acad Sci. 1999;884:292–304
  19. Stöver T, Yagi M, Raphael Y. Transduction of the contralateral ear after adenovirus-mediated cochlear gene transfer. Gene Ther. 2000;7:377–383
  20. Yu ZL, Han DM, Lin C, et al. Experimental study of transgenic expression in inner ear. Chin J Otorhinolaryngol. 2003;38(5):340–342

PII: S0196-0709(08)00008-2

doi: 10.1016/j.amjoto.2007.12.006

American Journal of Otolaryngology - Head and Neck Medicine and Surgery
Volume 30, Issue 1 , Pages 8-16 , January 2009

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