American Journal of Otolaryngology - Head and Neck Medicine and Surgery
Volume 30, Issue 1 , Pages 58-60, January 2009

Papillary thyroid carcinoma and familial adenomatous polyposis of the colon

Presented as a poster at The Triological Society 2007 Southern Section Meeting.

  • Kimberly A. Donnellan, MD

      Affiliations

    • Department of Otolaryngology and Communicative Sciences, University of Mississippi Medical Center, Jackson, MS, USA
    • Corresponding Author InformationCorresponding author. Department of Otolaryngology-Head and Neck Surgery, 2500 North State St., Jackson, MS 39216-4505. Tel.: +1 601 984 5160; fax: +1 601 984 5085.
    • ,
  • Steven A. Bigler, MD

      Affiliations

    • Department of Pathology, University of Mississippi Medical Center, Jackson, MS, USA
    • ,
  • Richard O. Wein, MD

      Affiliations

    • Department of Otolaryngology and Communicative Sciences, Tufts-New England Medical Center, Boston, MA, USA

Received 7 January 2008 published online 10 July 2008.

Abstract 

Objective

Case report and limited review of the literature on the topic of papillary thyroid carcinoma and familial adenomatous polyposis and its genetic associations.

Methods

A patient with multiple prior surgeries for colonic polyps, abdominal perineal resection for colorectal cancer, and wedge resection for metastatic adenocarcinoma (consistent with rectal primary) presented with a thyroid mass. Fine-needle aspiration demonstrated papillary thyroid carcinoma.

Results

The patient underwent total thyroidectomy. Pathologic examination revealed the cribriform-morular variant of papillary carcinoma that has been reported in patients with familial adenomatous polyposis.

Conclusions

Cribriform-morular variant of papillary thyroid carcinoma is an uncommon diagnosis known to be associated with familial adenomatous polyposis. Although the incidence is rare, this diagnosis should raise the clinician's suspicions to recommend both colorectal screening and genetic counseling for family members.

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PII: S0196-0709(08)00010-0

doi:10.1016/j.amjoto.2008.01.001

American Journal of Otolaryngology - Head and Neck Medicine and Surgery
Volume 30, Issue 1 , Pages 58-60, January 2009

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