Survival outcomes of squamous cell carcinoma arising from sinonasal inverted papilloma: report of 6 cases with systematic review and pooled analysis

Tanvetyanon, Tawee; Qin, Dahui; Padhya, Tapan; Kapoor, Rachna; McCaffrey, Judith; Trotti, Andy

doi:10.1016/j.amjoto.2008.02.005

« Previous Next »American Journal of Otolaryngology - Head and Neck Medicine and Surgery
Volume 30, Issue 1 , Pages 38-43, January 2009

Survival outcomes of squamous cell carcinoma arising from sinonasal inverted papilloma: report of 6 cases with systematic review and pooled analysis

Tawee Tanvetyanon, MD
- Head and Neck Program, H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL, USA
- Corresponding author. Head and Neck Program, H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, 12902 Magnolia Drive, Tampa, FL 33612, USA.
Dahui Qin, MD, PhD
- Head and Neck Program, H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL, USA
Tapan Padhya, MD
- Head and Neck Program, H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL, USA
Rachna Kapoor, MBBS, MPH
- Biostatistics Division, H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL, USA
Judith McCaffrey, MD
- Head and Neck Program, H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL, USA
Andy Trotti, MD
- Head and Neck Program, H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL, USA

Received 10 December 2007 published online 24 July 2008.

Abstract

Background

Inverted papilloma (IP) is an uncommon sinonasal tumor. Squamous cell carcinoma (SCC) is associated with IP in about 7% of cases. To date, there has been no pooled analysis to formulate a survival outcome associated with this rare condition.

Patients and methods

We retrospectively reviewed the medical records of patients with IP and SCC treated at our institution during 1999–2007. Including our series, a systematic review of literature on Medline database and pooled analysis were performed to establish a survival estimate.

Results

Six patients were identified. Squamous cell carcinoma was metachronous to the initial diagnosis of IP in 1 case and synchronous in 5 cases. Of 5 patients who had completed therapy at the time of this report, only 1 remained disease-free at 74 months. The median overall survival in our series was 33 months. Three patients developed distant metastases in brain, lung, bone, and liver. Literature review and pooled survival analysis consisting of 76 cases indicated a median overall survival of 126 months with 3- and 5-year survival rates of 63% and 61%, respectively.

Conclusion

Although the survival outcome of SCC arising from IP seems comparable with sinonasal SCCs, some patients with this disease do have a highly aggressive disease, including hematogenous distant metastasis. Overall, about 40% of patients will die of the disease within the first 3 years.