Effect of manganese-superoxide dismutase genetic polymorphisms IVS3-23T/G on noise susceptibility in Taiwan
Received 17 April 2008 published online 09 March 2009.
Abstract
Purpose
The aim of the study is to investigate the distribution of manganese-superoxide dismutase (SOD2) genetic polymorphisms IVS3-23T/G and their influence on noise susceptibility in Asians.
Materials and methods
Questionnaires about history of noise exposure were administered to factory workers, and audiometric data and blood specimens were obtained during their routine annual health examinations. The SOD2 typing was extended with polymerase chain reaction and screened with single-strand conformation polymorphism. The associations of genetic polymorphisms with noise-induced hearing loss (NIHL) were analyzed.
Results
The allele frequencies of T and G in the population of this study were 0.868 and 0.132, respectively. In 200 screened participants, individuals with T/G genotype were significantly more vulnerable to noise (adjusted odds ratio, 6.222; 95% confidence interval, 1.498–25.855) than the wild type (ie, T/T) by logistic regressions.
Conclusions
The distributions of SOD2 genetic polymorphisms for Asians are different from those reported on Europeans. Individuals with T/G genotype were more vulnerable to noise. This single nucleotide polymorphism is worthy of more studies for the application to NIHL monitoring.
aGraduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
bDepartment of Preventive Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
cDepartment of Otorhinolaryngology, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
dDepartment of Otorhinolaryngology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
eGraduate Institute of Occupational Safety and Health, College of Health Science, Kaohsiung Medical University, Kaohsiung, Taiwan
fDepartment of Occupational and Environmental Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
gFaculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
Corresponding author. Department of Otorhinolaryngology, Kaohsiung Medical University, No. 100, Shih-Chuan 1st Road, Kaohsiung City 807, Taiwan. Tel.: +886 7 3208264; fax: +886 7 3208264.
ABSTRACT