The preventive effect of mitomycin-C on the external auditory canal fibrosis in an experimentally induced animal model

Yoon, Yeo-Hoon; Park, Jae Yong; Park, Yong Ho

doi:10.1016/j.amjoto.2008.08.013

« Previous Next »American Journal of Otolaryngology - Head and Neck Medicine and Surgery
Volume 31, Issue 1 , Pages 9-13, January 2010

The preventive effect of mitomycin-C on the external auditory canal fibrosis in an experimentally induced animal model

Yeo-Hoon Yoon, PhD, MD
- Department of Otolaryngology-Head and Neck Surgery, Chungnam National University College of Medicine, Daejeon, Republic of Korea
Jae Yong Park, MD
- Department of Otolaryngology-Head and Neck Surgery, Chungnam National University College of Medicine, Daejeon, Republic of Korea
Yong Ho Park, PhD, MD
- Department of Otolaryngology-Head and Neck Surgery, Chungnam National University College of Medicine, Daejeon, Republic of Korea
- Research Institute for Medical Sciences, Chungnam National University College of Medicine, Daejeon, Republic of Korea
- Corresponding author. Department of Otolaryngology-Head and Neck Surgery, Chungnam National University Hospital, 640 Daesa-Dong, Chung-Gu, Daejeon, 301-040, South Korea. Tel.: +82 42 280 7697; fax: +82 42 253 4059.

Received 8 June 2008 published online 16 March 2009.

Abstract

Objective

The aim of this study was to investigate the preventive effect of mitomycin-C (MMC) on external auditory canal (EAC) fibrosis in an animal model.

Study design

This is a randomized, controlled animal study.

Subjects and methods

Sixteen guinea pigs were used for this study. After the skin of cartilaginous EAC was injured with an electrocautery, the cottonoid soaked in MMC solution with concentration of 0.4 mg/mL was topically applied for 5 minutes to the injured EAC in an MMC-treated group (n = 8). In addition, saline was applied in the control group (n = 8). At 4 weeks after injury, postsurgical changes of EAC were evaluated by histologic examination.

Results

External auditory canal fibrosis was induced by injury with electrocautery. The MMC-treated group showed less degree of fibrosis without differences in epithelialization and inflammatory cell infiltration.