American Journal of Otolaryngology - Head and Neck Medicine and Surgery
Volume 31, Issue 1 , Pages 9-13 , January 2010

The preventive effect of mitomycin-C on the external auditory canal fibrosis in an experimentally induced animal model

  • Yeo-Hoon Yoon, PhD, MD

      Affiliations

    • Department of Otolaryngology-Head and Neck Surgery, Chungnam National University College of Medicine, Daejeon, Republic of Korea
    • ,
  • Jae Yong Park, MD

      Affiliations

    • Department of Otolaryngology-Head and Neck Surgery, Chungnam National University College of Medicine, Daejeon, Republic of Korea
    • ,
  • Yong Ho Park, PhD, MD

      Affiliations

    • Department of Otolaryngology-Head and Neck Surgery, Chungnam National University College of Medicine, Daejeon, Republic of Korea
    • Research Institute for Medical Sciences, Chungnam National University College of Medicine, Daejeon, Republic of Korea
    • Corresponding Author InformationCorresponding author. Department of Otolaryngology-Head and Neck Surgery, Chungnam National University Hospital, 640 Daesa-Dong, Chung-Gu, Daejeon, 301-040, South Korea. Tel.: +82 42 280 7697; fax: +82 42 253 4059.

Received 8 June 2008

References 

  1. Becker BC, Tos M. Postinflammatory acquired atresia of the external auditory canal: treatment and results of surgery over 27 years. Laryngoscope. 1998;108:903–907
  2. Luong A, Roland PS. Acquired external auditory canal stenosis: assessment and management. Curr Opin Otolaryngol Head Neck Surg. 2005;13:273–276
  3. Roland PS. Chronic external otitis. Ear Nose Throat J. 2001;80:12–16
  4. Paparella MM, Kurkjain JM. Surgical treatment for chronic stenosing external otitis. Laryngoscope. 1966;56:232–245
  5. Chung JH, Cosenza MJ, Rahbar R, et al. Mitomycin C for the prevention of adhesion formation after endoscopic sinus surgery: a randomized, controlled study. Otolaryngol Head Neck Surg. 2002;126:468–474
  6. Rahbar R, Shapshay SM, Healy GB. Mitomycin: effects on laryngeal and tracheal stenosis, benefits, and complications. Ann Otol Rhinol Laryngol. 2001;110:1–6
  7. Battelino S, Hocevar-Boltezar I, Zargi M. Intraoperative use of mitomycin C in fibrous atresia of the external auditory canal. Ear Nose Throat J. 2005;84:776–779
  8. Banthia V, Selesnick SH. Mitomycin-C in the postsurgical ear canal. Otolaryngol Head Neck Surg. 2003;128:882–886
  9. Rahbar R, Shapshay SM, Healy GB, et al. Mitomycin; effects on laryngeal and tracheal stenosis, benefits, and complications. Ann Otol Rhinol Laryngol. 2001;110:1–6
  10. Slattery WH, Saadat P. Postinflammatory medial canal fibrosis. Am J Otol. 1997;18:294–297
  11. Birman CS, Fagan PA. Medial canal stenosis—chronic stenosing external otitis. Am J Otol. 1996;17:2–6
  12. Carls JL, Mendenhall WM, Morris CG, et al. External auditory canal stenosis after radiation therapy. Laryngoscope. 2002;112:1975–1978
  13. Bonding P, Tos M. Postinflammatory acquired atresia of the external auditory canal. Acta Otolaryngol. 1975;79:115–123
  14. McCary WS, Kryzer TC, Lambert PR. Application of split-thickness skin grafts for acquired diseases of the external auditory canal. Am J Otol. 1995;16:801–805
  15. Babu SC, Kartush JM, Patni A. Otologic effects of topical mitomycin C: phase I—evaluation of ototoxicity. Otol Neurotol. 2005;26:140–144
  16. Moody MW, Lang H, Spiess AC, et al. Topical application of mitomycin C to the middle ear is ototoxic in the gerbil. Otol Neurotol. 2006;27:1186–1192

PII: S0196-0709(08)00178-6

doi: 10.1016/j.amjoto.2008.08.013

American Journal of Otolaryngology - Head and Neck Medicine and Surgery
Volume 31, Issue 1 , Pages 9-13 , January 2010

Article Tools

* Image Usage & Resolution