American Journal of Otolaryngology - Head and Neck Medicine and Surgery
Volume 31, Issue 5 , Pages 309-314 , September 2010

The importance of vascular endothelial growth factor in the healing of acute tympanic membrane perforation

  • Kyu-Sup Cho, MD, PhD

      Affiliations

    • Department of Otorhinolaryngology, Pusan National University School of Medicine, Busan, South Korea
    • ,
  • Dong-Gun Lee, MD, PhD

      Affiliations

    • Department of Otorhinolaryngology, Pusan National University School of Medicine, Busan, South Korea
    • ,
  • Dong-Hoon Shin, MD

      Affiliations

    • Department of Pathology, Medical Research Institute, Pusan National University School of Medicine, Busan, South Korea
    • ,
  • Young-Dae Park, MD

      Affiliations

    • Department of Otorhinolaryngology, Pusan National University School of Medicine, Busan, South Korea
    • ,
  • Kyong-Myong Chon, MD, PhD

      Affiliations

    • Department of Otorhinolaryngology, Pusan National University School of Medicine, Busan, South Korea
    • Corresponding Author InformationCorresponding author. Department of Otorhinolaryngology, Pusan National University School of Medicine, 1-10 Ami-dong, Seo-gu, Busan 602-739, South Korea. Tel.: +82 51 240 7330; fax: +82 51 248 1248.

Received 23 November 2008

References 

  1. Johnson AP, Smallman LA, Kent SE. The mechanism of healing of tympanic membrane perforations. A two-dimensional histological study in guinea pigs. Acta Otolaryngol. 1990;109:406–415
  2. Ozkaptan Y, Gerek M, Simsek S, et al. Effects of fibroblast growth factor on the healing process of tympanic membrane perforations in an animal model. Eur Arch Otorhinolaryngol. 1997;254(Suppl 1):S2–S5
  3. Ramalho JR, Bento RF. Healing of subacute tympanic membrane perforations in chinchillas treated with epidermal growth factor and pentoxifylline. Otol Neurotol. 2006;27:720–727
  4. Guneri EA, Tekin S, Yilmaz O, et al. The effects of hyaluronic acid, epidermal growth factor, and mitomycin in an experimental model of acute traumatic tympanic membrane perforation. Otol Neurotol. 2003;24:371–376
  5. Mondain M, Ryan A. Epidermal growth factor and fibroblast growth factor are induced in guinea-pig tympanic membrane following traumatic perforation. Acta Otolaryngol. 1995;115:50–54
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  9. Ferrara N. Vascular endothelial growth factor. Trends Cardiovasc Med. 1993;3:244–250
  10. Corral CJ, Siddiqui A, Wu L, et al. Vascular endothelial growth factor is more important than basic fibroblastic growth factor during ischemic wound healing. Arch Surg. 1999;134:200–205
  11. Gan L, Fagerholm P, Palmblad J. Vascular endothelial growth factor (VEGF) and its receptor VEGFR-2 in the regulation of corneal neovascularization and wound healing. Acta Ophthalmol Scand. 2004;82:557–563
  12. Knutsson J, Bagger-Sjoback D, von Unge M. Distribution of different collagen types in the rat's tympanic membrane and its suspending structures. Otol Neurotol. 2007;28:486–491
  13. Wang WQ, Wang ZM, Chi FL. Spontaneous healing of various tympanic membrane perforations in the rat. Acta Otolaryngol. 2004;124:1141–1144
  14. Ishimoto S, Ishibashi T. Induction of growth factor expression is reduced during healing of tympanic membrane perforations in glucocorticoid-treated rats. Ann Otol Rhinol Laryngol. 2002;111:947–953
  15. Sheikh AY, Gibson JJ, Rollins MD, et al. Effect of hyperoxia on vascular endothelial growth factor levels in a wound model. Arch Surg. 2000;135:1293–1297
  16. Ishibashi T, Shinogami M, Ishimoto SI, et al. Induction of KGF, basic FGF, and TGFalpha mRNA expression during healing of experimental TM perforations. Acta Otolaryngol. 1998;118:701–704
  17. Vrabec JT, Schwaber MK, Davidson JM, et al. Evaluation of basic fibroblast growth factor in tympanic membrane repair. Laryngoscope. 1994;104:1059–1064
  18. Buyten J, Kaufman G, Ryan M. Effects of ciprofloxacin/dexamethasone and ofloxacin on tympanic membrane perforation healing. Otol Neurotol. 2007;28:887–890
  19. Ma Y, Zhao H, Zhou X. Topical treatment with growth factors for tympanic membrane perforations: progress towards clinical application. Acta Otolaryngol. 2002;122:586–599
  20. Thomas KA. Vascular endothelial growth factor: a potent and selective angiogenic agent. J Biol Chem. 1996;271:603–606

PII: S0196-0709(09)00053-2

doi: 10.1016/j.amjoto.2009.03.005

American Journal of Otolaryngology - Head and Neck Medicine and Surgery
Volume 31, Issue 5 , Pages 309-314 , September 2010

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