American Journal of Otolaryngology - Head and Neck Medicine and Surgery
Volume 32, Issue 1 , Pages 13-18 , January 2011

Pathologic correlations of otologic symptoms in acute lymphocytic leukemia

  • Kyoichi Terao, MD, PhD

      Affiliations

    • Department of Otolaryngology, University of Minnesota, Minneapolis, Minnesota, USA
    • International Hearing Foundation, Minneapolis, Minnesota, USA
    • Department of Otolaryngology, Kinki University School of Medicine, Osaka, Japan
    • ,
  • Sebahattin Cureoglu, MD

      Affiliations

    • Department of Otolaryngology, University of Minnesota, Minneapolis, Minnesota, USA
    • Paparella Ear Head and Neck Institute, Minneapolis, Minnesota, USA
    • Corresponding Author InformationCorresponding author. Department of Otolaryngology, University of Minnesota, Room 210, Lions Research Building, 2001, 6th Street, SE, Minneapolis, MN 55455, USA. Tel.: +1 612 626 9883; fax: +1 612 626 9871.
    • ,
  • Patricia A. Schachern, BS

      Affiliations

    • Department of Otolaryngology, University of Minnesota, Minneapolis, Minnesota, USA
    • ,
  • Michael M. Paparella, MD

      Affiliations

    • Department of Otolaryngology, University of Minnesota, Minneapolis, Minnesota, USA
    • International Hearing Foundation, Minneapolis, Minnesota, USA
    • Paparella Ear Head and Neck Institute, Minneapolis, Minnesota, USA
    • ,
  • Norimasa Morita, MD, PhD

      Affiliations

    • Department of Otolaryngology, University of Minnesota, Minneapolis, Minnesota, USA
    • International Hearing Foundation, Minneapolis, Minnesota, USA
    • ,
  • Shigenobu Nomiya, MD, PhD

      Affiliations

    • Department of Otolaryngology, University of Minnesota, Minneapolis, Minnesota, USA
    • International Hearing Foundation, Minneapolis, Minnesota, USA
    • ,
  • Taro Inagaki, MD, PhD

      Affiliations

    • Department of Otolaryngology, University of Minnesota, Minneapolis, Minnesota, USA
    • International Hearing Foundation, Minneapolis, Minnesota, USA
    • ,
  • Kazunori Mori, MD, PhD

      Affiliations

    • Department of Otolaryngology, Kinki University School of Medicine, Osaka, Japan
    • ,
  • Kiyotaka Murata, MD, PhD

      Affiliations

    • Department of Otolaryngology, Kinki University School of Medicine, Osaka, Japan

Received 30 June 2009

References 

  1. Druss JG. Aural manifestations of leukemia. Arch Otolaryngol Head Neck Surg. 1945;42:267–274
  2. Shanbrom E, Finch SC. The auditory manifestations of leukemia. Yale J Biol Med. 1958;31:144–156
  3. Paparella MM, Berlinger NT, Oda M, et al. Otological manifestations of leukemia. Laryngoscope. 1973;83:1510–1526
  4. Taljebini M, Linthicum FH. Hearing loss in chronic lymphocytic leukemia. Otol Neurotol. 2007;28:282–283
  5. Millot F, Klossec JM, Brizard F, et al. Recurrence of childhood acute lymphoblastic leukemia presenting as a tumor of the middle ear: a case report. J Pediatr Hematol. 1997;19:351–353
  6. Au WY, Chan CF, Chim CS, et al. External auditory canal tumor: a rare chloroma in acute promyelocytic leukemia with a complete response to arsenic trioxide. J Clin Oncol. 2001;20:3993–3995
  7. Zechner G, Altmann F. The temporal bone in leukemia histopathological studies. Ann Otol Rhinol Laryngol. 1969;78:375–387
  8. Proctor B, Lindsay JR. Tumors involving the petrous pyramid of the temporal bone. Arch Otolaryngol Head Neck Surg. 1947;46:180–194
  9. Jahn AF, Farkashidy J, Berman JM. Metastatic tumors in the temporal bone—a pathophysiologic study. J Otolaryngol. 1979;8:85–95
  10. Okura SI, Kaga K. Temporal bone pathology of leukemia and malignant lymphoma with middle ear effusion. Auris Nasus Larynx. 1994;21:1–7
  11. Wiernik PH, Serpick AA. Glanulocytic sarcoma (chloroma). Blood. 1970;35:361–369
  12. Schuknecht HF, Igarashi M, Chasin WD. Inner ear hemorrhage in leukemia. A case report. Laryngoscope. 1965;75:662–668
  13. Breccia M, Petti MC, Testi AM, et al. Ear involvement in acute promyelocytic leukemia at relapse: a disease-associated ‘sanctuary’?. Leukemia. 2002;16:1127–1130
  14. Aikawa T, Ohtani I. Temporal bone findings in central nervous system leukemia. Am J Otolaryngol. 1991;12:320–325
  15. Hoshino T, Hiraide F, Nomura Y. Metastatic tumor of the inner ear: a histopathological report. J Laryngol Otol. 1972;86:697–707
  16. LaVenuta F, Moore JA. Involvement of the inner ear in acute stem cell leukemia. Report of two cases. Ann Otol Rhinol Laryngol. 1972;81:132–137
  17. Hallpike CS, Harrison MS. Clinical and pathological observations of a case of leukemia with deafness and vertigo. J Laryngol Otol. 1950;64:427–430
  18. Sklansky BD, Jafek BW, Wiernik PH. Otolaryngologic manifestations of acute leukemia. Laryngoscope. 1974;84:210–230
  19. Ozçakar L, Akinci A, Ozgöçmen S, et al. Bell's palsy as an early manifestation of acute lymphoblastic leukemia. Ann Hematol. 2003;82:124–126

☆ This study was supported by the International Hearing Foundation, the Starkey Foundation, and the Society for Promotion of International Oto-Rhino-Laryngology.

PII: S0196-0709(09)00170-7

doi: 10.1016/j.amjoto.2009.08.006

American Journal of Otolaryngology - Head and Neck Medicine and Surgery
Volume 32, Issue 1 , Pages 13-18 , January 2011

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