American Journal of Otolaryngology - Head and Neck Medicine and Surgery
Volume 32, Issue 1 , Pages 19-23 , January 2011

Simvastatin and Ginkgo biloba in the treatment of subacute tinnitus: a retrospective study of 94 patients

Received 21 May 2009

References 

  1. Miller JM, Ren TY, Nuttall AL. Studies of inner ear blood flow in animals and human beings. Otolaryngol Head Neck Surg. 1995;112:101–113
  2. Sidman JD, Prazma J, Pulver SH, et al. Cochlea and heart as end-organs in small vessel disease. Ann Otol Rhinol Laryngol. 1988;97:9–13
  3. Saito T, Sato K, Saito H. An experimental study of auditory dysfunction associated with hyperlipoproteinemia. Arch Otorhinolaryngol. 1986;243:242–245
  4. Gratton MA, Wright CG. Alterations of inner ear morphology in experimental hypercholesterolemia. Hear Res. 1992;61:97–105
  5. Feron O, Dessy C, Desager JP, et al. Hydroxy-methylglutaryl-coenzyme A reductase inhibition promotes endothelial nitric oxide synthase activation through a decrease in caveolin abundance. Circulation. 2001;103:113–118
  6. Nguyen TV, Brownell WE. Contribution of membrane cholesterol to outer hair cell lateral wall stiffness. Otolaryngol Head Neck Surg. 1998;119:14–20
  7. Canis M, Schmid J, Olzowy B, et al. The influence of cholesterol on the motility of cochlear outer hair cells and the motor protein prestin. Acta Otolaryngol. 2009;[electronic publication ahead of print]
  8. Suckfull M. Fibrinogen and LDL apheresis in treatment of sudden hearing loss: a randomised multicentre trial. Lancet. 2002;360:1811–1817
  9. Renders L, Mayer-Kadner I, Koch C, et al. Efficacy and drug interactions of the new HMG-CoA reductase inhibitors cerivastatin and atorvastatin in CsA-treated renal transplant recipients. Nephrol Dial Transplant. 2001;16:141–146
  10. Brechtelsbauer PB, Nuttall AL, Miller JM. Basal nitric oxide production in regulation of cochlear blood flow. Hear Res. 1994;77:38–42
  11. Fessenden JD, Schacht J. The nitric oxide/cyclic GMP pathway: a potential major regulator of cochlear physiology. Hear Res. 1998;118:168–176
  12. Joyce NC, Haire MF, Palade GE. Contractile proteins in pericytes. I. Immunoperoxidase localization of tropomyosin. J Cell Biol. 1985;100:1379–1386
  13. Dujovne CA, Harris WS, Altman R, et al. Effect of atorvastatin on hemorheologic-hemostatic parameters and serum fibrinogen levels in hyperlipidemic patients. Am J Cardiol. 2000;85:350–353
  14. Drew S, Davies E. Effectiveness of Ginkgo biloba in treating tinnitus: double blind, placebo controlled trial. BMJ. 2001;322:73
  15. Rejali D, Sivakumar A, Balaji N. Ginkgo biloba does not benefit patients with tinnitus: a randomized placebo-controlled double-blind trial and meta-analysis of randomized trials. Clin Otolaryngol Allied Sci. 2004;29:226–231
  16. Goebel G, Hiller W. The tinnitus questionnaire. A standard instrument for grading the degree of tinnitus. Results of a multicenter study with the tinnitus questionnaire. HNO. 1994;42:166–172
  17. Olzowy B, Canis M, Hempel JM, et al. Effect of atorvastatin on progression of sensorineural hearing loss and tinnitus in the elderly: results of a prospective, randomized, double-blind clinical trial. Otol Neurotol. 2007;28:455–458

PII: S0196-0709(09)00209-9

doi: 10.1016/j.amjoto.2009.09.004

American Journal of Otolaryngology - Head and Neck Medicine and Surgery
Volume 32, Issue 1 , Pages 19-23 , January 2011