American Journal of Otolaryngology - Head and Neck Medicine and Surgery
Volume 32, Issue 4 , Pages 286-290 , July 2011

Head and neck squamous cell carcinoma from an unknown primary site

  • Audrey Wallace, MSN

      Affiliations

    • Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, FL, USA
    • ,
  • Greg M. Richards, MD

      Affiliations

    • Department of Human Oncology, University of Wisconsin College of Medicine, Madison, WI, USA
    • ,
  • Paul M. Harari, MD

      Affiliations

    • Department of Human Oncology, University of Wisconsin College of Medicine, Madison, WI, USA
    • ,
  • Jessica M. Kirwan, MA

      Affiliations

    • Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, FL, USA
    • ,
  • Christopher G. Morris, MS

      Affiliations

    • Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, FL, USA
    • ,
  • Haritha Katakam, BS

      Affiliations

    • Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, FL, USA
    • ,
  • William M. Mendenhall, MD

      Affiliations

    • Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, FL, USA
    • Corresponding Author InformationCorresponding author. Department of Radiation Oncology, University of Florida College of Medicine, 2000 SW Archer Rd, PO Box 100385, Gainesville, FL 32610-0385, USA. Tel.: +1 352 265 0287; fax: +1 352 265 0759.

Received 9 March 2010

References 

  1. Mendenhall WM, Mancuso AA, Parsons JT, et al. Diagnostic evaluation of squamous cell carcinoma metastatic to cervical lymph nodes from an unknown head and neck primary site. Head Neck. 1998;20:739–744
  2. Mendenhall WM. Unknown primary squamous cell carcinoma of the head and neck. Curr Cancer Ther Rev. 2005;1:167–174
  3. Patel RS, Clark J, Wyten R, et al. Squamous cell carcinoma from an unknown head and neck primary site: a “selective treatment” approach. Arch Otolaryngol Head Neck Surg. 2007;133:1282–1287
  4. Madani I, Vakaet L, Bonte K, et al. Intensity-modulated radiotherapy for cervical lymph node metastases from unknown primary cancer. Int J Radiat Oncol Biol Phys. 2008;71:1158–1166
  5. Barker CA, Morris CG, Mendenhall WM. Larynx-sparing radiotherapy for squamous cell carcinoma from an unknown head and neck primary site. Am J Clin Oncol. 2005;28:445–448
  6. American Joint Committee on Cancer. AJCC Cancer Staging Handbook, 6th ed. New York: Springer-Verlag;2002;215.
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  8. Cox DR. Regression models and life tables—series B (methodological). J R Stat Soc. 1972;34:187–220
  9. Colletier PJ, Garden AS, Morrison WH, et al. Postoperative radiation for squamous cell carcinoma metastatic to cervical lymph nodes from an unknown primary site: outcomes and patterns of failure. Head Neck. 1998;20:674–681
  10. Reddy SP, Marks JE. Metastatic carcinoma in the cervical lymph nodes from an unknown primary site: results of bilateral neck plus mucosal irradiation vs. ipsilateral neck irradiation. Int J Radiat Oncol Biol Phys. 1997;37:797–802
  11. Grau C, Johansen LV, Jakobsen J, et al. Cervical lymph node metastases from unknown primary tumours: results from a national survey by the Danish Society for Head and Neck Oncology. Radiother Oncol. 2000;55:121–129
  12. Iganej S, Kagan R, Anderson P, et al. Metastatic squamous cell carcinoma of the neck from an unknown primary: management options and patterns of relapse. Head Neck. 2002;24:236–246
  13. Erkal HS, Mendenhall WM, Amdur RJ, et al. Squamous cell carcinomas metastatic to cervical lymph nodes from an unknown head-and-neck mucosal site treated with radiation therapy alone or in combination with neck dissection. Int J Radiat Oncol Biol Phys. 2001;50:55–63
  14. Cianchetti M, Mancuso AA, Amdur R, et al. Diagnostic evaluation of squamous cell carcinoma metastatic to cervical lymph nodes from an unknown head and neck primary site. Laryngoscope. 2009;119:2348–2354
  15. Mendenhall WM, Amdur RJ, Palta JR. Intensity-modulated radiotherapy in the standard management of head and neck cancer: promises and pitfalls. J Clin Oncol. 2006;24:2618–2623
  16. Mendenhall WM, Mancuso AA. Radiotherapy for head and neck cancer–is the “next level” down?. Int J Radiat Oncol Biol Phys. 2009;73:645–646
  17. Mendenhall WM, Riggs CE, Amdur RJ, et al. Altered fractionation and/or adjuvant chemotherapy in definitive irradiation of squamous cell carcinoma of the head and neck. Laryngoscope. 2003;113:546–551
  18. Liauw SL, Mancuso AA, Amdur RJ, et al. Postradiotherapy neck dissection for lymph node-positive head and neck cancer: the use of computed tomography to manage the neck. J Clin Oncol. 2006;24:1421–1427
  19. Yeung AR, Liauw SL, Amdur RJ, et al. Lymph node-positive head and neck cancer treated with definitive radiotherapy: can treatment response determine the extent of neck dissection?. Cancer. 2008;112:1076–1082

☆ Disclosure: The authors have no conflicts of interest to declare.

PII: S0196-0709(10)00088-8

doi: 10.1016/j.amjoto.2010.05.004

American Journal of Otolaryngology - Head and Neck Medicine and Surgery
Volume 32, Issue 4 , Pages 286-290 , July 2011

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