American Journal of Otolaryngology - Head and Neck Medicine and Surgery
Volume 32, Issue 4 , Pages 291-300 , July 2011

Animal model of radiogenic bone damage to study mandibular osteoradionecrosis

  • Marc Cohen, MD

      Affiliations

    • Division of Head and Neck Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    • ,
  • Ichiro Nishimura, DDS, DMSc, DMD

      Affiliations

    • UCLA School of Dentistry, Weintraub Center for Reconstructive Biotechnology, Los Angeles, CA, USA
    • ,
  • Matthew Tamplen, BS

      Affiliations

    • Division of Head and Neck Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    • ,
  • Akishige Hokugo, DDS, PhD

      Affiliations

    • UCLA School of Dentistry, Weintraub Center for Reconstructive Biotechnology, Los Angeles, CA, USA
    • ,
  • John Beumer, DDS, MS

      Affiliations

    • UCLA School of Dentistry, Weintraub Center for Reconstructive Biotechnology, Los Angeles, CA, USA
    • ,
  • Michael L. Steinberg, MD

      Affiliations

    • Department of Radiation Oncology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    • ,
  • Jeffrey D. Suh, MD

      Affiliations

    • Division of Head and Neck Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    • ,
  • Elliot Abemayor, MD, PhD

      Affiliations

    • Division of Head and Neck Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    • ,
  • Vishad Nabili, MD

      Affiliations

    • Division of Head and Neck Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    • Corresponding Author InformationCorresponding author. Division of Head and Neck Surgery, David Geffen School of Medicine at UCLA, 10833 LeConte Ave, CHS RM 62-132, Los Angeles, CA 90095-1624, USA. Tel.: +1 310 709 7970; fax: +1 310 206 1393.

Received 27 April 2010

References 

  1. Beumer J, Silverman S, Benak SB. Hard and soft tissue necroses following radiation therapy for oral cancer. J Prosthet Dent. 1972;27:640–644
  2. Marx RE. Osteoradionecrosis: a new concept of its pathophysiology. J Oral Maxillofac Surg. 1983;41:283–288
  3. Hutchinson IL. Complications of radiotherapy in head and neck: an orofacial surgeon's view. In:  Tobias JS,  Thomas PRM editor. Current radiation oncology. London: Arnold; 1996;p. 144–177
  4. Harris M. The conservative management of osteoradionecrosis of the mandible with ultrasound therapy. Br J Oral Maxillofac Surg. 1992;30:313–318
  5. Niehoff P, Springer IN, Acil Y, et al. HDR brachytherapy irradiation of the jaw—as a new experimental model of radiogenic bone damage. J Craniomaxillofac Surg. 2008;36:203–209
  6. Beumer J, Harrison R, Sanders B, et al. Preradiation dental extractions and the incidence of bone necrosis. Head Neck Surg. 1983;5:514–521
  7. Schwartz HC, Kagan AR. Osteoradionecrosis of the mandible: scientific basis for clinical staging. Am J Clin Oncol. 2002;25:168–171
  8. Nabili V, Brodie HA, Neverov NI, et al. Chronology of labyrinthitis ossificans induced by Streptococcus pneumoniae meningitis. Laryngoscope. 1999;109:931–935
  9. Regaud C. Sur la necrosedes os attente par un processus cancereux et traits par les radiaions. Compt Rend Soc Biol. 1922;87:629
  10. Meyer I. Infectious diseases of the jaws. J Oral Surg. 1970;28:17–26
  11. Delanian S, Lefaix JL. The radiation-induced fibroatrophic process: therapeutic perspective via the antioxidant pathway. Radiother Oncol. 2004;73:119–131
  12. Delanian S, Depondt J, Lefaix JL. Major healing of refractory mandible osteoradionecrosis after treatment combining pentoxifylline and tocopherol: a phase II trial. Head Neck. 2005;27:114–123
  13. Horn Y, Sela MN, Shlomi B, et al. Effect of irradiation-timing on the initial socket healing in rats. Int J Oral Surg. 1979;8:457–461
  14. Guglielmotti MB, Ubios AM, Cabrini RL. Alveolar wound healing after x-irradiation: a histologic, radiographic, and histometric study. J Oral Maxillofac Surg. 1986;44:972–976
  15. Koga DH, Salvajoli JV, Alves FA. Dental extractions and radiotherapy in head and neck oncology: review of the literature. Oral Dis. 2008;14:40–44
  16. Lorente CA, Song BZ, Donoff RB. Healing of bony defects in the irradiated and unirradiated rat mandible. J Oral Maxillofac Surg. 1992;50:1305–1309
  17. Kurihashi T, Iwata H, Nasu M, et al. Experimental study on wound healing of alveolar bone sockets in the rat maxilla after x-ray irradiation. Odontology. 2002;90:35–42
  18. Beumer J, Seto B. Dental extractions in the irradiated patient. Spec Care Dentist. 1981;1:166–173
  19. Epstein JB, Wong FL, Stevenson-Moore P. Osteoradionecrosis: clinical experience and a proposal for classification. J Oral Maxillofac Surg. 1987;45:104–110

☆ Presented at the American Academy of Otolaryngology Head and Neck Surgery Annual Meeting, October 6, 2009, San Diego, CA.

☆☆ Justification for additional authors: This project entailed expertise from multiple areas with each author playing a key role in providing input and resources including Head and Neck Surgical Oncology (Drs Cohen, Suh, and Abemayor), Microvascular Reconstruction (Dr Nabili), Dental biology (Drs Nishimura, Hokugo, and Beumer), and Radiation access and physicist input (Dr Steinberg).

PII: S0196-0709(10)00094-3

doi: 10.1016/j.amjoto.2010.06.001

American Journal of Otolaryngology - Head and Neck Medicine and Surgery
Volume 32, Issue 4 , Pages 291-300 , July 2011

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