American Journal of Otolaryngology - Head and Neck Medicine and Surgery
Volume 33, Issue 1 , Pages 6-13 , January 2012

Snail as a novel marker for regional metastasis in head and neck squamous cell carcinoma

  • Abie H. Mendelsohn, MD

      Affiliations

    • Division of Head and Neck Surgery, Department of Surgery, Center, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    • Corresponding Author InformationCorresponding author. David Geffen School of Medicine at UCLA, Division of Head and Neck Surgery, 62-132 CHS, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA. Tel.: +(310) 825 5179; fax: +(310) 206 7393.
    • ,
  • Chi K. Lai, MD

      Affiliations

    • Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    • ,
  • I. Peter Shintaku, PhD

      Affiliations

    • Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    • ,
  • Michael C. Fishbein, MD

      Affiliations

    • Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    • ,
  • Katherine Brugman, BS

      Affiliations

    • Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    • ,
  • David A. Elashoff, PhD

      Affiliations

    • Department of Biostatistics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    • ,
  • Elliot Abemayor, MD, PhD

      Affiliations

    • Division of Head and Neck Surgery, Department of Surgery, Center, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    • Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    • ,
  • Steven M. Dubinett, MD

      Affiliations

    • Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    • Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    • ,
  • Maie A. St. John, MD, PhD

      Affiliations

    • Division of Head and Neck Surgery, Department of Surgery, Center, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    • Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA

Received 26 June 2010

  • Image Result

    Proposed cellular pathway. Chronic inflammation increases IL-1β, which increases COX-2 activation. The COX-2 metabolite, PGE2, leads to increased Snail expression, which actively blocks the promoter r

    Proposed cellular pathway. Chronic inflammation increases IL-1β, which increases COX-2 activation. The COX-2 metabolite, PGE2, leads to increased Snail expression, which actively blocks the promoter region of E-cadherin.

  • Image Result
    Head and neck squamous cell carcinoma Snail immunohistochemistry—1+. This specimen exhibits islands of well-differentiated HNSCC (original magnification ×100) exhibiting 1+ (<25%) staining with more p

    Head and neck squamous cell carcinoma Snail immunohistochemistry—1+. This specimen exhibits islands of well-differentiated HNSCC (original magnification ×100) exhibiting 1+ (<25%) staining with more pronounced snail expression staining at the periphery of the lobules.

  • Image Result
    Head and neck squamous cell carcinoma Snail immunohistochemistry—4+. This specimen exhibits infiltrating clusters of poorly differentiated squamous cell carcinoma (original magnification ×100) exhibit

    Head and neck squamous cell carcinoma Snail immunohistochemistry—4+. This specimen exhibits infiltrating clusters of poorly differentiated squamous cell carcinoma (original magnification ×100) exhibiting 4+ (>75%) staining.

PII: S0196-0709(10)00251-6

doi: 10.1016/j.amjoto.2010.11.018

American Journal of Otolaryngology - Head and Neck Medicine and Surgery
Volume 33, Issue 1 , Pages 6-13 , January 2012

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